71047-49-9

Basic information

• Product Name: Ethanone, 1-[2-[(4-chlorophenyl)amino]-4-methyl-5-thiazolyl]-
• CAS NO: 71047-49-9
• Molecular Formula: C12H11ClN2OS
• Molecular Weight: 266.751
• Mol File: 71047-49-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-[(4-chlorophenyl)amino]-4-methyl-5-thiazolyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-[(4-chlorophenyl)amino]-4-methyl-5-thiazolyl]-(71047-49-9)
• EPA Substance Registry System: Ethanone, 1-[2-[(4-chlorophenyl)amino]-4-methyl-5-thiazolyl]-(71047-49-9)

Safety Data

• Hazardous Substances Data: 71047-49-9(Hazardous Substances Data)

Upstream product

• 3043-28-5 3-bromopentane-2,4-dione 
• 3696-23-9 N-(4-chlorophenyl)thiourea 
• 1694-29-7 3-chloropentane-2,4-dione 
• 333-20-0 potassium thioacyanate 
• 106-47-8 4-chloro-aniline 
• 123-54-6 acetylacetone 

Downstream Products

• 71047-65-9 1-[2-(4-chloro-anilino)-4-methyl-thiazol-5-yl]-3-(4-chloro-phenyl)-propenone 
• 112834-38-5 (4-Chloro-phenyl)-[4-methyl-5-(5-phenyl-4,5-dihydro-isoxazol-3-yl)-thiazol-2-yl]-amine 
• 112833-80-4 (4-Chloro-phenyl)-[4-methyl-5-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-thiazol-2-yl]-amine 
• 112833-85-9 (4-Chloro-phenyl)-[4-methyl-5-(5-p-tolyl-4,5-dihydro-1H-pyrazol-3-yl)-thiazol-2-yl]-amine 
• 112834-43-2 (4-Chloro-phenyl)-[4-methyl-5-(5-p-tolyl-4,5-dihydro-isoxazol-3-yl)-thiazol-2-yl]-amine 
• 112833-88-2 (4-Chloro-phenyl)-[5-(5-furan-2-yl-4,5-dihydro-1H-pyrazol-3-yl)-4-methyl-thiazol-2-yl]-amine 
• 112834-46-5 (4-Chloro-phenyl)-[5-(5-furan-2-yl-4,5-dihydro-isoxazol-3-yl)-4-methyl-thiazol-2-yl]-amine 
• 112833-89-3 (4-Chloro-phenyl)-[4-methyl-5-(5-thiophen-2-yl-4,5-dihydro-1H-pyrazol-3-yl)-thiazol-2-yl]-amine 
• 112834-47-6 (4-Chloro-phenyl)-[4-methyl-5-(5-thiophen-2-yl-4,5-dihydro-isoxazol-3-yl)-thiazol-2-yl]-amine 
• 112834-45-4 (4-Chloro-phenyl)-[4-methyl-5-(5-pyridin-2-yl-4,5-dihydro-isoxazol-3-yl)-thiazol-2-yl]-amine 
• 112833-87-1 (4-Chloro-phenyl)-[4-methyl-5-(5-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl)-thiazol-2-yl]-amine 
• 112833-82-6 (4-Chloro-phenyl)-{5-[5-(4-chloro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-thiazol-2-yl}-amine 
• 112834-40-9 (4-Chloro-phenyl)-{5-[5-(4-chloro-phenyl)-4,5-dihydro-isoxazol-3-yl]-4-methyl-thiazol-2-yl}-amine 
• 112833-83-7 {5-[5-(4-Bromo-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-thiazol-2-yl}-(4-chloro-phenyl)-amine 

Relevant articles and documents

Mechanochemical synthesis of 5-acetylthiazole: A step toward green and sustainable chemistry

Mechanochemical synthesis of 5-acetylthiazole derivatives by one-pot three-component procedure over Silica Sulfuric acid under solvent-free conditions, has been developed. The durability of the catalyst was tested. The environmentally benign protocol introduced herein characterized by no hazardous organic solvent used, recyclability of the catalyst up to five runs without loss of its catalytic activity and high yields of products that confirm the utilization of some green chemistry principles in the mentioned protocol.

Synthesis of 5-acetyl-2-arylamino-4-methylthiazole thiosemicarbazones under microwave irradiation and their in vitro anticancer activity

A series of 21 new tri- and tetra-cyclic thiosemicarbazone derivatives were prepared via the condensation of morpholine, piperazine or N-(4-methoxyphenyl)piperazine with seven methyl hydrazine-carbodithioate derivatives of 5-acetyl-2-arylamino-4-methylthiazoles under microwave irradiation. All compounds were tested for their cytotoxic activity in vitro against human gastric, lung and breast cancer cell lines. The results showed that some of the compounds displayed moderate anticancer activity. The most potent compound, a morpholinosubstituted analogue, exhibited significant activity against human breast cancer cells.

Study on condensation of N-aryl thioureas with 3-bromo-acetylacetone: Synthesis of aminothiazoles and iminodihydrothiazoles, and their in vitro antiproliferative activity on human cervical cancer cells

The condensation of N-aryl thioureas with 3-bromo-acetylacetone in neutral solvent acetone not only led to 5-acetyl-4-methyl-2-(substituted anilino) thiazoles 3 but also 2-imino-3-(substituted phenyl)-4-methyl-5-acetyl-2,3- dihydrothiazoles 4. Further study found that different reaction solvents displayed an important role toward the ratio of aminothiazoles 3 and iminodihydrothiazoles 4, and the reaction scope was extended. A plausible mechanism involving solvent effect and in situ hydrobromic acid catalyzation was proposed. Some selected isomers exhibited moderate in vitro antiproliferative activity on human cervical cancer cell lines (Hela, Siha).