71047-51-3

Basic information

• Product Name: Ethanone, 1-[2-[(4-ethoxyphenyl)amino]-4-methyl-5-thiazolyl]-
• CAS NO: 71047-51-3
• Molecular Formula: C14H16N2O2S
• Molecular Weight: 276.359
• Mol File: 71047-51-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-[(4-ethoxyphenyl)amino]-4-methyl-5-thiazolyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-[(4-ethoxyphenyl)amino]-4-methyl-5-thiazolyl]-(71047-51-3)
• EPA Substance Registry System: Ethanone, 1-[2-[(4-ethoxyphenyl)amino]-4-methyl-5-thiazolyl]-(71047-51-3)

Safety Data

• Hazardous Substances Data: 71047-51-3(Hazardous Substances Data)

Upstream product

• 3043-28-5 3-bromopentane-2,4-dione 
• 880-29-5 1-(4-ethoxyphenyl)thiourea 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 112833-58-6 (E)-1-[2-(4-Ethoxy-phenylamino)-4-methyl-thiazol-5-yl]-3-pyridin-2-yl-propenone 
• 112833-60-0 (E)-1-[2-(4-Ethoxy-phenylamino)-4-methyl-thiazol-5-yl]-3-thiophen-2-yl-propenone 
• 112833-55-3 (E)-1-[2-(4-Ethoxy-phenylamino)-4-methyl-thiazol-5-yl]-3-(2-hydroxy-phenyl)-propenone 
• 112833-56-4 (E)-3-(4-Bromo-phenyl)-1-[2-(4-ethoxy-phenylamino)-4-methyl-thiazol-5-yl]-propenone 
• 112834-14-7 (4-Ethoxy-phenyl)-{4-methyl-5-[5-(4-nitro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-thiazol-2-yl}-amine 
• 112834-70-5 (4-Ethoxy-phenyl)-{4-methyl-5-[5-(4-nitro-phenyl)-4,5-dihydro-isoxazol-3-yl]-thiazol-2-yl}-amine 
• 112834-16-9 (4-Ethoxy-phenyl)-{5-[5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-thiazol-2-yl}-amine 
• 112834-72-7 (4-Ethoxy-phenyl)-{5-[5-(4-methoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-4-methyl-thiazol-2-yl}-amine 
• 112834-67-0 2-{3-[2-(4-Ethoxy-phenylamino)-4-methyl-thiazol-5-yl]-4,5-dihydro-isoxazol-5-yl}-phenol 
• 112834-11-4 2-{5-[2-(4-Ethoxy-phenylamino)-4-methyl-thiazol-5-yl]-3,4-dihydro-2H-pyrazol-3-yl}-phenol 
• 112834-13-6 {5-[5-(4-Bromo-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-thiazol-2-yl}-(4-ethoxy-phenyl)-amine 
• 112834-12-5 {5-[5-(4-Chloro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-thiazol-2-yl}-(4-ethoxy-phenyl)-amine 
• 112834-69-2 {5-[5-(4-Bromo-phenyl)-4,5-dihydro-isoxazol-3-yl]-4-methyl-thiazol-2-yl}-(4-ethoxy-phenyl)-amine 
• 112834-68-1 {5-[5-(4-Chloro-phenyl)-4,5-dihydro-isoxazol-3-yl]-4-methyl-thiazol-2-yl}-(4-ethoxy-phenyl)-amine 

Relevant articles and documents

Study on condensation of N-aryl thioureas with 3-bromo-acetylacetone: Synthesis of aminothiazoles and iminodihydrothiazoles, and their in vitro antiproliferative activity on human cervical cancer cells

The condensation of N-aryl thioureas with 3-bromo-acetylacetone in neutral solvent acetone not only led to 5-acetyl-4-methyl-2-(substituted anilino) thiazoles 3 but also 2-imino-3-(substituted phenyl)-4-methyl-5-acetyl-2,3- dihydrothiazoles 4. Further study found that different reaction solvents displayed an important role toward the ratio of aminothiazoles 3 and iminodihydrothiazoles 4, and the reaction scope was extended. A plausible mechanism involving solvent effect and in situ hydrobromic acid catalyzation was proposed. Some selected isomers exhibited moderate in vitro antiproliferative activity on human cervical cancer cell lines (Hela, Siha).