880-29-5

Basic information

• Product Name: 1-(4-ETHOXYPHENYL)-2-THIOUREA
• Synonyms: P-ETHOXYPHENYLTHIOUREA;N-(4-ETHOXYPHENYL)THIOUREA;(4-ethoxyphenyl)-thioure;(4-ethoxyphenyl)thiourea;1-(p-ethoxyphenyl)-2-thio-ure;1-(p-ethoxyphenyl)-2-thiourea;4-thioureidophenetole;1-(4-ETHOXYPHENYL)-2-THIOUREA
• CAS NO: 880-29-5
• Molecular Formula: C₉H₁₂N₂OS
• Molecular Weight: 196.27
• EINECS: 212-912-8
• Mol File: 880-29-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 173°C
• Boiling Point: 324.3 °C at 760 mmHg
• Flash Point: 149.9 °C
• Appearance: /
• Density: 1.241 g/cm³
• Vapor Pressure: 0.000248mmHg at 25°C
• Refractive Index: 1.654
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1-(4-ETHOXYPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ETHOXYPHENYL)-2-THIOUREA(880-29-5)
• EPA Substance Registry System: 1-(4-ETHOXYPHENYL)-2-THIOUREA(880-29-5)

Safety Data

• Statements: 25
• Safety Statements: 22-36/37/39
• RIDADR: 2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 880-29-5(Hazardous Substances Data)

Usage

General Description

1-(4-Ethoxyphenyl)-2-thiourea is a chemical compound with the molecular formula C9H12N2OS. It is a thiourea derivative with a phenyl group that is substituted by an ethoxy group. 1-(4-ETHOXYPHENYL)-2-THIOUREA is often used in organic synthesis and as a reagent for the preparation of various pharmaceutical compounds. It is also known for its potential antifungal and antibacterial properties, making it a candidate for use in the development of new drugs. Additionally, 1-(4-ethoxyphenyl)-2-thiourea has been studied for its potential applications in the treatment of cancer and diabetes due to its ability to inhibit certain enzymes and pathways involved in these diseases.

InChI:InChI=1/C9H12N2OS/c1-2-12-8-5-3-7(4-6-8)11-9(10)13/h3-6H,2H2,1H3,(H3,10,11,13)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 156-43-4 4-Ethoxyaniline 
• 64289-08-3 1-(4-ethoxy-phenyl)-dithiobiuret 
• 3460-49-9 1-ethoxy-4-isothiocyanatobenzene 
• 333-20-0 potassium thioacyanate 
• 83697-75-0 N-(4-ethoxyphenyl)-N'-benzoylthiocarbamide 

Downstream Products

• 31102-68-8 (4-ethoxy-phenyl)-thiazolo[4,5-b]quinoxalin-2-yl-amine 
• 31200-23-4 3-(4-ethoxy-phenyl)-3H-thiazolo[4,5-b]quinoxalin-2-ylideneamine 
• 98274-62-5 17β-[2-(4-ethoxy-anilino)-thiazol-4-yl]-17α-hydroxy-androst-4-en-3-one 
• 95438-14-5 4-amino-3-(4-ethoxy-phenyl)-5-phenyl-3H-thiazol-2-ylideneamine 
• 78864-12-7 (4-ethoxy-phenyl)-[5-(4-fluoro-2-methyl-phenyl)-thiazol-2-yl]-amine 
• 78864-19-4 (4-ethoxy-phenyl)-[5-(3-fluoro-4-methoxy-phenyl)-thiazol-2-yl]-amine 
• 78864-15-0 (4-ethoxy-phenyl)-[5-(2-fluoro-5-methyl-phenyl)-thiazol-2-yl]-amine 
• 78864-09-2 (4-ethoxy-phenyl)-[5-(4-fluoro-3-methyl-phenyl)-thiazol-2-yl]-amine 
• 71047-51-3 5-acetyl-4-methyl-2-(p-ethoxyphenylamino)-thiazole 
• 19353-48-1 (4-ethoxy-phenyl)-(4-phenyl-thiazol-2-yl)-amine 
• 78864-05-8 (4-ethoxy-phenyl)-[5-(4-fluoro-phenyl)-thiazol-2-yl]-amine 
• 56158-71-5 (1,3-diphenyl-1H-pyrazolo[3,4-d]thiazol-5-yl)-(4-ethoxy-phenyl)-amine 
• 56158-65-7 6-(4-ethoxy-phenyl)-1,3-diphenyl-1,6-dihydro-pyrazolo[3,4-d]thiazol-5-one 
• 115541-05-4 2-(p-ethoxyphenylamino)-4-(2'-pyrazinyl)thiazole 

Relevant articles and documents

Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists

Piperine is an alkaloid responsible for the pungency of black pepper. In this study, piperine isolated from Piper nigrum L. was hydrolyzed under basic condition to obtain piperic acid and was used as precursor to carry out the synthesis of twenty piperine derivatives containing benzothiazole moiety. All the benzothiazole derivatives were evaluated for their antidiabetic potential by OGT test followed by assessment of active derivatives on STZ-induced diabetic model. It was observed that nine of twenty novel piperine analogues (5b, 6a-h), showed significantly higher antidiabetic activity in comparison with rosiglitazone (standard). Furthermore, these active derivatives were evaluated for their action as PPAR-γ agonists demonstrating their mechanism of action. The effects on body weight, lipid peroxidation, and hepatotoxicity after administration with active derivatives were also studied to further establish these derivatives as lead molecules for treatment of diabetes with lesser side-effects.

HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS

Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS

Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.