71050-40-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxythiophene-3-carboxylic acid is used as a synthetic intermediate for the development of new pharmaceuticals, leveraging its unique structure and reactivity to create novel drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Methoxythiophene-3-carboxylic acid is utilized as a key component in the synthesis of various agrochemicals, contributing to the development of innovative products for crop protection and enhancement of agricultural yields.
Used in Organic Compounds Synthesis:
4-Methoxythiophene-3-carboxylic acid is employed as a building block in the synthesis of organic compounds, enabling the creation of a wide range of chemical entities with diverse applications in various industries.
Used in Dyes and Pigments Production:
4-METHOXYTHIOPHENE-3-CARBOXYLIC ACID is used as a crucial ingredient in the production of dyes and pigments, offering a broad spectrum of color options and enhancing the performance characteristics of these products.
Used in Material Science:
4-Methoxythiophene-3-carboxylic acid has potential applications in material science, where its unique structure and reactivity can be harnessed to develop new materials with improved properties and functionalities.

InChI:InChI=1/C6H6O3S/c1-9-5-3-10-2-4(5)6(7)8/h2-3H,1H3,(H,7,8)

Upstream product

• 65369-22-4 methyl 4-methoxy-3-thiophenecarboxylate 
• 78071-37-1 4-bromo-3-thiophenecarboxylic acid methyl ester 

Downstream Products

• 682358-47-0 1-(2',6'-dichlorobenzoyl)-5-(4-methoxy-3-thiophenylcarbonyl)amino-2-methylindole 
• 133659-14-0 2-chloro-3-methoxy-thiophene-4-carboxylic acid 
• 65369-22-4 methyl 4-methoxy-3-thiophenecarboxylate 

Relevant academic research and scientific papers

Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 2. 6,6-dimethylbicyclo[3.1.1]heptane derivatives

In an earlier paper, we reported that novel prostaglandin D2 (PGD2) receptor antagonists having the bicyclo[2.2.1]heptane ring system as a prostaglandin skeleton were a potent new class of antiallergic agents and suppressed various allergic inflammatory responses such as those observed in conjunctivitis and asthma models. In the present study, we synthesized PGD2 receptor antagonists having the 6,6-dimethylbicyclo [3.1.1]heptane ring system. These derivatives have the amide moiety, in contrast to those with the bicyclo[2.2.1]heptane ring system, which have the sulfonamide group. The derivatives having the 6,6-dimethylbicyclo[3.1.1]heptane ring also exhibited strong activity in PGD2 receptor binding and cAMP formation assays. In in vivo assays such as allergic rhinitis, conjunctivitis, and asthma models, these series of derivatives showed excellent pharmacological profiles. In particular, compound 45 also effectively suppressed eosinophil infiltration in allergic rhinitis and asthma models. This compound (45, S-5751) is now being developed as a promising alternative antiallergic drug candidate.

Organic compounds and their use as pharmaceuticals

A pharmaceutical compound of the formula STR1 in which R1, R2 and R3 independently are hydrogen, hydroxy, halo, nitro, amino, C2-5 acylamino, C1-4 alkyl, --CHO, --CH2 OH, --CH2 OC1-4 alkyl, --COOH, --COC1-3 alkyl, --CH(OH)C1-3 alkyl, C1-4 alkoxy, C2-4 alkenyloxy, C1-4 alkylthio, C1-4 alkylsulphinyl, C1-4 alkylsulphonyl, N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio, optionally substituted phenylsulphinyl, optionally substituted phenylsulphonyl or optionally substituted phenylsulphonamido, or R1 and R2 together form a C3-5 alkylene bridge; provided that at least one of R2 and R3 is C1-4 alkoxy or C2-4 alkenyloxy; and X is (i) --(CH2)n N(R4)2 where each R4 independently is C1-4 alkyl, C2-4 alkenyl or optionally substituted C6 H5 CH2 --, and n is 1, 2 or 3, or (ii) a 5- to 8-membered alicyclic group containing one or two nitrogen atoms and directly attached to the amido nitrogen or attached by a C1-3 alkylene chain; and salts and esters thereof.