78071-37-1

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-bromothiophene-3-carboxylate is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 4-bromothiophene-3-carboxylate serves as an essential intermediate for the production of agrochemicals. Its role in the synthesis of these compounds aids in the development of effective solutions for agricultural applications, such as pest control and crop protection.
Used in Fragrance and Flavor Industry:
Methyl 4-bromothiophene-3-carboxylate is employed as a component in the creation of fragrances and flavors. Its strong, fruity odor makes it a valuable addition to the formulation of various scented products, enhancing the sensory experience of consumers.
Used in Organic Compounds Synthesis:
As a versatile intermediate, Methyl 4-bromothiophene-3-carboxylate is also used in the synthesis of other organic compounds. Its chemical properties enable it to be a building block for a wide range of organic molecules, expanding its applications in the chemical industry.

Upstream product

• 69363-85-5 methyl 4-aminothiophene-3-carboxylate 
• 3141-26-2 3,4-dibromothiophene 
• 79-22-1 methyl chloroformate 
• 67-56-1 methanol 
• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 
• 72899-51-5 4-Bromo-thiophene-3-carbonyl chloride 

Downstream Products

• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 
• 65369-22-4 methyl 4-methoxy-3-thiophenecarboxylate 
• 917113-46-3 Methyl-4-(2-nitrophenyl)-3-thiophencarboxylat 
• 71050-40-3 4-methoxy-3-thiophenecarboxylic acid 
• 57279-53-5 6-phenyl-5H-thieno[3,4-c]pyridin-4-one 
• 70438-00-5 4-ethoxy-thiophene-3-carboxylic acid 
• 57279-64-8 4-(2-oxo-2-phenylethyl)thiophene-3-carboxylic acid 
• 1334393-52-0 4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate 
• 23062-42-2 4-phenylthiophene-3-carboxylic acid 
• 38695-71-5 methyl 4-phenylthiophene-3-carboxylate 

Relevant academic research and scientific papers

p-diaminobenzene derivative as potassium channel regulator, preparation method and medical applications thereof

The invention relates to a p-diaminobenzene derivative as a potassium channel regulator, a preparation method and medical applications thereof, and specifically discloses a compound represented by a general formula A or a pharmaceutically acceptable salt

Catalyst-Controlled Regiodivergent Dehydrogenative Heck Reaction of 4-Arylthiophene/Furan-3-Carboxylates

A catalyst-controlled regiodivergent dehydrogenative Heck reaction of 4-arylthiophene/furan-3-carboxylates has been realized. Use of a palladium catalyst led to the C-5 alkenylation through electronic palladation, while a ruthenium catalyst favored the C-2 alkenylation with the assistance of a directing group. This reaction exhibited good to excellent regioselectivities. (Figure presented.).

PIPERIDINYLOXY LACTONE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to piperidinyloxy lactone compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the piperidinyloxy lactone compounds described herein in the potential treatment or preventi

Efficient synthesis of novel glutamate homologues and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

A convenient synthesis of four new enantiomerically pure acidic amino acids is reported and their affinity at ionotropic glutamate receptors was determined. The new compounds are higher homologues of glutamic acid in which the molecular complexity has bee

Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells

A novel family of potent dual inhibitors of CK2 and the Pim kinases was discovered by modifying the scaffolds of tricyclic Pim inhibitors. Several analogs were active at single digit nanomolar IC50 values against CK2 and the Pim isoforms Pim-1

1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS

The invention relates to compounds of formula I: where X, HAr, a, and R1 through R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

CONDENSED QUINOLINES AS PROTEIN KINASE MODULATORS

The invention relates in part to molecules of formula (I) having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the inv

Thieno[3,4-c]quinoline-4-yl-amines - Synthesis and investigation of activity against malaria

The 4-aryl derivative 3, obtained by Suzuki cross coupling of the methyl 4-bromothiophene-3-carboxylate (2) with 2-nitrophenylboronic acid cyclizes under reductive conditions pH-dependant to yield the tricyclic hydroxamic acid 4 or the lactam 5. The chlorothieno[3,4-c]quinoline 6 was formed by reaction of the lactam 5 with P,P-dichlorophenylphosphinoxide. The amines 7-14 were synthesized from the chloroimine 6. Compounds 7a,b, 8, 9, 10b, 11, 12 and 14a, b were tested for in vitro antimalarial activity using the chloroquine sensitive 3D7 and the chloroquine resistant Plasmodium falciparum strain Dd2. The highest activity were shown by 10b with IC50 values of 130 nM and 50 nM, respectively and by 11 with IC50 values of 190 nM and 44 nM, respectively.

Synthesis of thiophenecarboxamides, thieno[3,4-c]pyridin-4(5H)-ones and thieno[3,4-d]pyrimidin-4(3H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)

Inhibitors of poly(ADP-ribose)polymerase (PARP) inhibit repair of damaged DNA and thus potentiate radiotherapy and chemotherapy of cancer. Treatment of 3-cyanothiophene with potassium nitrate and concentrated sulphuric acid gave 5-nitrothiophene-3-carboxamide. 4-Nitrothiophene-2-carboxamide and 5-nitrothiophene-2-carboxamide were formed similarly from 2-cyanothiophene. Reduction with tin(II) chloride gave the corresponding aminothiophenecarboxamide salts which were isolated via their N-Cbz derivatives. Lithiation of 3,4-dibromothiophene at -116°C and quenching with alkyl chloroformates gave 4-bromothiophene-3-carboxylates, which were hydrolysed to 4-bromothiophene-3-carboxylic acid. Hurtley reactions with the enolates of pentane-2,4-dione and of 1-phenylbutane-1,3-dione, followed by acyl cleavage, led to 4-(2-oxopropyl)thiophene-3-carboxylic acid and 4-phenacylthiophene-3-carboxylic acid, respectively. Condensation with ammonia in acetic acid gave 6-methyl- and 6-phenyl-thieno[3,4-c]pyridin-4-ones, which were selectively nitrated at the 1- and 7-positions or were dinitrated. Ethyl 4-acetamido- and 4-benzamido-thiophene-3-carboxylates were cyclised to 2-methyl- and 2-phenyl-thieno[3,4-d][1,3]oxazin-4-ones, respectively. Ring-opening with ammonia and recyclisation led to 2-substituted thieno[3,4-d]pyrimidin-4-ones. The aminothiophenecarboxamides are analogues of 3-aminobenzamide, a selective inhibitor of poly(ADP-ribose)polymerase (PARP); the thienopyridinones and the thienopyrimidinones are analogues of isoquinolin-1-ones and quinazolin-4-ones, respectively, which inhibit this enzyme. In preliminary assays, several thienopyridinones and thienopyrimidinones showed potent inhibitory activity against PARP. Copyright (C) 1999 Published by Elsevier Science Ltd.

Synthesis and antitumour activity of new derivatives of flavone-8- acetic acid (FAA). Part 31): 2-Heteroaryl derivatives

A range of 14 derivatives of flavone-8-acetic acid (FAA) with a heterocyclic substituent in place of the 2-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. Some of the compounds, notably 2c,d and s, showed significant in vivo activity and these require further studies in order to evaluate their potential for development.