71069-26-6Relevant academic research and scientific papers
Chiral Phosphinites Derived from α-D-Glucofuranose and α-L-Idofuranose. A Comparison to Chiral Phosphines in Asymmetric Hydrogenation
Johnson, Thomas H.,Rangarajan, G.
, p. 62 - 65 (2007/10/02)
Two chiral phosphinites and two chiral phosphines, which are derivatives of α-D-glucofuranose and α-L-idofuranose, were prepared and used as ligands in rhodium-catalyzed asymmetric hydrogenations.Six substrates were studied.Unlike phosphinites prepared from α-D-glucopyranose, the phosphinites prepared in this study were effective in inducing asymmetry in the hydrogenations of atropic acid and α-methylcinnamic acid.The phosphinites were frequently better chiral modifiers than phosphines when an acetamido group was not present in the substrate.
