7107-59-7

Basic information

• Product Name: benzyl (4-hydroxyphenyl)carbamate
• CAS NO: 7107-59-7
• Molecular Formula: C₁₄H₁₃NO₃
• Molecular Weight: 243.2579
• Mol File: 7107-59-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 380.4°C at 760 mmHg
• Flash Point: 183.8°C
• Density: 1.293g/cm³
• Vapor Pressure: 2.5E-06mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: benzyl (4-hydroxyphenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (4-hydroxyphenyl)carbamate(7107-59-7)
• EPA Substance Registry System: benzyl (4-hydroxyphenyl)carbamate(7107-59-7)

Safety Data

• Hazardous Substances Data: 7107-59-7(Hazardous Substances Data)

Usage

General Description

Benzyl (4-hydroxyphenyl)carbamate, also known as benzyl p-hydroxyphenyl carbamate or benzyl phenol carbamate, is an organic chemical compound with the molecular formula C14H13NO3. It is a white, crystalline solid that is commonly used as a sunscreen agent and ultraviolet (UV) absorber in cosmetic and personal care products. Benzyl (4-hydroxyphenyl)carbamate works by absorbing UV light and converting it into harmless heat, providing protection against the damaging effects of sun exposure. It is considered safe for use in skincare products and has been approved for use in the European Union and other regions. However, it is important to follow safety guidelines and use products containing this compound as directed to avoid any potential adverse effects.

Upstream product

• 123-30-8 4-amino-phenol 
• 501-53-1 benzyl chloroformate 
• 104-57-4 benzyl formate 
• 54840-15-2 4-N-tert-butoxycarbonylaminophenol 
• 16801-63-1 benzyl N-(4-oxocyclohexyl)carbamate 
• 97389-23-6 4-[(2-tetrahydropyranyloxy)methyl]aniline 
• 20443-91-8 2-(4-nitrophenoxy)tetrahydropyran 
• 100-02-7 4-nitro-phenol 
• 174359-47-8 p-tetrahydropyran-2-yloxy-N-(benzyloxycarbonyl)aminobenzene 

Downstream Products

• 110876-77-2 [4-(2-piperidino-ethoxy)-phenyl]-carbamic acid benzyl ester 
• 174359-48-9 (S)-2-tert-Butoxycarbonylamino-propionic acid 4-benzyloxycarbonylamino-phenyl ester 
• 174359-52-5 [2-(2-tert-Butoxycarbonylamino-acetylamino)-acetylamino]-acetic acid 4-benzyloxycarbonylamino-phenyl ester 
• 156-43-4 4-Ethoxyaniline 
• 166383-73-9 ethyl 4-(benzyloxycarbonylamino)phenoxyacetate 
• 1195781-05-5 benzyl {4-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate 

Relevant articles and documents

Positioning of an unprecedented 1,5-oxaza spiroquinone scaffold into SMYD2 inhibitors in epigenetic space

Lysine methyltransferases are important regulators of epigenetic signaling and are emerging as a novel drug target for drug discovery. This work demonstrates the positioning of novel 1,5-oxaza spiroquinone scaffold into selective SET and MYND domain-conta

One stone two birds: Cobalt-catalyzed in situ generation of isocyanates and benzyl alcohols for the synthesis of N-aryl carbamates

An efficient method for the synthesis of N-aryl carbamates from N-Boc-protected amines has been developed. The cobalt-catalyzed in situ generation of isocyanates from N-Boc-protected amines and benzyl alcohols from benzyl formates has been achieved for the first time, which in turn furnished the corresponding benzyl carbamates in moderate to high yields. The reaction was catalyzed by CoI2 with tris-(4-dimethylaminophenyl)-phosphine as the ligand and zinc powder as the reductant. The developed reaction conditions were found to be compatible for aromatic amines with both electron-donating and -withdrawing substituents.

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane x receptor antagonists

Pregnane X receptor (PXR), a member of the NR1I nuclear receptor family, acts as a xenobiotic sensor and a paramount transcriptional regulator of drug-metabolizing enzymes and transporters. The overexpression of PXR in various cancer cells indicates the importance of PXR as a drug target for countering multidrug resistance in anticancer treatments. We describe the discovery of novel bazedoxifene-scaffold-based PXR antagonists inspired by the marine sulfated steroids solomonsterol A and B as natural leads. A luciferase reporter assay on a PXR-transfected HepG2 cell line identified compounds 19-24 as promising PXR antagonists. Further structure-activity relationship studies of the most active PXR antagonist from the series (compound 20, IC50 = 11 μM) revealed the importance of hydroxyl groups as hydrogen-bond donors for PXR antagonistic activity. PXR antagonists 20 and 24 (IC50 = 14 μM), in addition to the downregulation of PXR expression, exhibited inhibition of PXR-induced CYP3A4 expression, which illustrates their potential to suppress PXR-regulated phase-I drug metabolism.