71083-59-5Relevant academic research and scientific papers
Radical cyclizations to quinolone and isoquinolone systems under oxidative and reductive conditions
Osornio, Yazmin M.,Miranda, Luis D.,Cruz-Almanza, Raymundo,Muchowski, Joseph M.
, p. 2855 - 2858 (2007/10/03)
Radical cyclizations to quinolone and isoquinolone systems under Fenton-type and n-Bu3SnH-mediated conditions are described. For N-iodoalkylquinolones, ca. 3:1 mixtures of oxidative cyclization products at C-2, and unexpectedly at C-8, were obtained under both conditions. Five- or six-membered oxidative cyclization products were obtained from N-iodoalkylisoquinolones under Fenton-type conditions, whereas n-Bu 3SnH-mediated reactions gave products of reductive cyclization in the five, six, and seven-membered series.
Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
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, (2008/06/13)
Compounds of the following formula are described: STR1 in which n is 0, 1 or 2, R1 is C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylsulphonyl, trifluoromethyl, halo or nitro, and R2 and R3 are each independently hydrogen or C1-4 alkyl, and salts thereof. The compounds are useful in the treatment of immediate hypersensitivity conditions and are prepared by reaction of the appropriate formylquinolone with malonic acid, ylid or phosphonate.
