71083-65-3 Usage
Main properties
1. Chemical compound
2. Molecular formula: C10H5FN2O
3. Quinoline derivative
4. Contains a fluorine atom at the 8th position
5. Contains a keto group at the 4th position
6. Contains a cyano group at the 3rd position
7. Used as a building block for synthesis of pharmaceuticals and agrochemicals
8. Versatile reactivity
9. Ability to form various functional groups
10. Studied for potential anti-inflammatory, antibacterial, and antifungal properties
11. Presence of fluorine atom enhances pharmacological properties and bioavailability
Specific content
1. Molecular formula: C10H5FN2O
2. Fluorine atom at 8th position
3. Keto group at 4th position
4. Cyano group at 3rd position
5. Used for synthesis of pharmaceuticals and agrochemicals
6. Anti-inflammatory properties
7. Antibacterial properties
8. Antifungal properties
9. Presence of fluorine enhances pharmacological properties and bioavailability.
Check Digit Verification of cas no
The CAS Registry Mumber 71083-65-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,0,8 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 71083-65:
(7*7)+(6*1)+(5*0)+(4*8)+(3*3)+(2*6)+(1*5)=113
113 % 10 = 3
So 71083-65-3 is a valid CAS Registry Number.
71083-65-3Relevant articles and documents
Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu7Positive Allosteric Modulator Tool Compound
Reed, Carson W.,Kalbfleisch, Jacob J.,Wong, Madison J.,Washecheck, Jordan P.,Hunter, Ashton,Rodriguez, Alice L.,Blobaum, Anna L.,Conn, P. Jeffrey,Niswender, Colleen M.,Lindsley, Craig W.
, p. 1773 - 1779 (2020/10/19)
Herein, we report the discovery of the first selective and CNS penetrant mGlu7 PAM (VU6027459) derived from a "molecular switch"within a selective mGlu7 NAM chemotype. VU6027459 displayed CNS penetration in both mice (Kp = 2.74) and rats (Kp= 4.78), it was orally bioavailable in rats (%F = 69.5), and undesired activity at DAT was ablated.
