71103-75-8Relevant academic research and scientific papers
Manganese-Catalyzed Multicomponent Synthesis of Pyrimidines from Alcohols and Amidines
Deibl, Nicklas,Kempe, Rhett
supporting information, p. 1663 - 1666 (2017/02/05)
The development of catalytic reactions for synthesizing different compounds from alcohols to save fossil carbon feedstock and reduce CO2emissions is of high importance. Replacing rare noble metals with abundantly available 3d metals is equally important. We report a manganese-complex-catalyzed multicomponent synthesis of pyrimidines from amidines and up to three alcohols. Our reaction proceeds through condensation and dehydrogenation steps, permitting selective C?C and C?N bond formations. β-Alkylation reactions are used to multiply alkylate secondary alcohols with two different primary alcohols to synthesize fully substituted pyrimidines in a one-pot process. Our PN5P-Mn-pincer complexes efficiently catalyze this multicomponent process. A comparison of our manganese catalysts with related cobalt catalysts indicates that manganese shows a reactivity similar to that of iridium but not cobalt. This analogy could be used to develop further (de)hydrogenation reactions with manganese complexes.
Facile synthesis of triarylpyrimidines with microwave-irradiated reactions of N-phenacylpyridinium chloride
Wu, Ping,Cai, Xi-Mei,Wang, Qi-Fang,Yan, Chao-Guo
, p. 223 - 229 (2007/10/03)
In a system of ammonium acetate and acetic acid under microwave irradiation, N-phenacylpyridinium chloride 1 reacted with 2 mol of aromatic aldehydes 2a-h to give 2,4,6-triarylpyrimidine 3a-h, reacted with pyridinecarboxaldehyde 4a-c and acetophenone 5 to yield bipyridine derivatives 6a-c. The structure of the products was characterized with 1H NMR, 13C NMR, IR, and mass spectroscopy. Copyright Taylor & Francis Group, LLC.
A NOVEL CONVENIENT ONE STEP PYRIMIDINE SYNTHESIS
Weis, A. L.,Rosenbach, V.
, p. 1453 - 1454 (2007/10/02)
A new method for the preparation of pyrimidines by condensation of β-dicarbonyl compounds, ammonium salts and carbonyl containing substances has been developed.
