71104-24-0Relevant academic research and scientific papers
Cross-Coupling between Difluorocarbene and Carbene-Derived Intermediates Generated from Diazocompounds for the Synthesis of gem-Difluoroolefins
Zheng, Jian,Lin, Jin-Hong,Yu, Liu-Ying,Wei, Yun,Zheng, Xing,Xiao, Ji-Chang
supporting information, p. 6150 - 6153 (2016/01/09)
Cross-coupling between difluorocarbene and carbene-derived intermediates generated from diazocompounds was developed to give gem-difluoroolefins, which constitutes a fast practical pathway to achieve hindered gem-difluoroolefins. The cross-coupling between difluorocarbene and aryl diazoacetates proceeded smoothly in the presence of a copper source, whereas its coupling with diaryl diazomethanes occurred well under metal-free conditions. A mechanism involving a copper-difluorocarbene complex was proposed.
