1140-14-3Relevant articles and documents
Metal-free, visible-light-mediated transformation of aryl diazonium salts and (hetero)arenes: An efficient route to aryl ketones
Gu, Lijun,Jin, Cheng,Liu, Jiyan
, p. 3733 - 3736 (2015)
A visible-light-catalyzed synthesis of aryl ketones from aryldiazonium salts, CO and (hetero)arenes at room temperature is discovered. This transformation represents an efficient and attractive synthetic utilization of aryl diazonium salts.
Photoenolization/nucleophilic addition enables direct access to 3-alkyl-3-hydroxy-indolin-2-ones
Wang, Zhi-Lv,Tang, Li,Zeng, Wei-Mei,He, Yan-Hong,Guan, Zhi
, (2022/03/27)
A light-driven, catalyst- and additive-free photoenolization/nucleophilic addition reaction for the synthesis of 3-benzyl-3-hydroxyindolin-2-ones is presented. In this reaction, 2-methylbenzophenones undergo light-induced enolization process to afford hydroxy-o-quinodimethanes (hydroxy-o-QDMs), which are then immediately captured by the electrophilic isatins. The reaction utilizes green and clean light energy to realize the C–H activation of the inert benzyl position of 2-methylbenzophenones. This method tolerates a wide scope of substrates and provides concise access to a series of novel 3-benzyl-3-hydroxyindolin-2-ones with 60–99% yields.
Carbon-wrapped Fe-Ni bimetallic nanoparticle-catalyzed Friedel-Crafts acylation for green synthesis of aromatic ketones
Bao, Shouxin,Hu, Dianwen,Jia, Mingjun,Lei, Zhenyu,Liu, Jingyao,Song, Xiaojing,Sun, Hao,Zhang, Hao,Zhang, Wenxiang,Zhao, Chen
, p. 7943 - 7954 (2021/12/27)
Developing highly efficient and durable eco-friendly heterogeneous catalysts for the Friedel-Crafts acylation (FCA) reaction has been a long-term and significant target, yet remains a great challenge. Herein, a series of Fe-Ni alloy nanoparticles (NPs) encapsulated inside N-doped carbon spheres (FexNi1?x@NC) was rationally fabricated by pyrolyzing the Fe-Ni bimetallic metal-organic frameworks (BMOFs-FexNi1?x) to this end. Various characterization results demonstrated that FeNi alloy NPs (25 nm) covered by a thin carbon shell (5 nm) were uniformly distributed throughout the entire carbon-based composite. A number of oxidized metal species (Fe3+, Ni2+) are present on the surface of the inner bimetallic core, which should be the main source of catalytically active centers of the carbon-wrapped metal NP catalysts. The composition-optimized Fe0.8Ni0.2@NC with relatively higher positive surface charges exhibited the highest catalytic activity and excellent stability for the acylation of aromatic compounds with acyl chlorides. The density functional theory calculations revealed that the catalytic activity of the FexNi1?x@NC catalysts could arise from the electron transfer,i.e., from the outermost layer of the carbon shell to the inner positively charged Fe-based metal NPs, which can lead to a positive charge distribution (by acting as weak Lewis acid sites) on the external surface of the carbon-encapsulated metal NP catalysts. In this case, the external carbon shell can function as ‘chainmail’ to transfer the Lewis acidity (positive charge), and also to protect the inner metal core from the destructive reaction environment, thus resulting in the formation of highly efficient and durable FCA catalysts.
Visible light-driven direct synthesis of ketones from aldehydes via C[sbnd]H bond activation using NiCu nanoparticles adorned on carbon nano onions
Heydari, Akbar,Khorsandi, Zahra,Metkazini, S. Fatemeh Mohammadi,Varma, Rajender S.
, (2021/11/09)
An efficient, straightforward and high yield synthetic approach is described for the direct synthesis of diaryl ketones via the C[sbnd]H bond activation of aldehydes using NiCu nanoparticles adorned on carbon nano onions as an efficient heterogeneous catalyst under the irradiation of a mercury-vapor lamp (400 w) via simple workup. This C[sbnd]H bond activation reaction appears simple and convenient with a wide substrate scope in view of its excellent synthesis prowess as illustrated in the preparation of new-approved anti-Alzheimer and anti-HIV medicinal compounds under greener and mild reaction conditions; catalyst could be recycled and reused five times without any loss of catalytic activity.
