71114-74-4Relevant academic research and scientific papers
Divergent Synthesis of Substituted Amino-1,2,4-triazole Derivatives
Jia, Changqing,Li, Jia-Qi,Qin, Zhaohai,Singh, Thishana,Su, Wangcang,Xiao, Yumei,Yang, Dongyan,Zhao, Fenghai
supporting information, p. 1901 - 1910 (2021/05/18)
A divergent efficient assembly of disubstituted 1,2,4-triazoles was established by cyclization of readily accessible N ′-nitro-2-hydrocarbylidene-hydrazinecarboximidamides with moderate to excellent yields under mild reaction conditions. This divergent synthetic strategy was achieved simply by varying the reaction conditions. Under acidic conditions, amino-1,2,4-triazoles were obtained by an intramolecular redox reaction involving the NO 2group. Control experiments and DFT studies revealed that this transformation proceeds via an intramolecular 1,3-hydride transfer pathway leading to HNO 2elimination. Under neutral conditions with water as the solvent, nitroimino-1,2,4-triazoles were obtained by oxidative intramolecular annulation under air.
4-(4-chlorphenyl)-5-(4-chlorphenyl)-4H-1,2,4-triazole-3-amine and application thereof
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, (2019/05/08)
The invention relates to the technical field of medicines, and particularly relates to 4-(4-chlorphenyl)-5-(4-chlorphenyl)-4h-1,2,4-triazole-3-amine and the application of 4-(4-chlorphenyl)-5-(4-chlorphenyl)-4h-1,2,4-triazole-3-amine. The invention provid
