7112-20-1Relevant academic research and scientific papers
Regio- and stereoselective acylation of saturated carbocycles via Norrish-Yang photocyclization
Kamijo, Shin,Hoshikawa, Tamaki,Inoue, Masayuki
supporting information; experimental part, p. 872 - 874 (2010/03/26)
A regio- and stereoselective acylation of saturated carbocycles has been achieved through two-step reactions involving the Norrish-Yang photocyclization of 1,2-diketones and subsequent ring opening of the α-hydroxy-cyclobutanones. The C-H activation of the carbocycle proceeds regioselectively at vicinal to the diketone moiety resulting in stereoselective formation of cis-fused bicycles. The following C-C cleavage affords vicinally cis-acylated carbocycles. Predictability, generality, and practicality of the present strategy have been demonstrated using variously modified saturated carbocycles.
