71121-95-4Relevant academic research and scientific papers
Synthesis and circular dichroism spectroscopic investigations of oligomeric β-peptoids with α-chiral side chains
Norgren, Anna S.,Zhang, Suode,Arvidsson, Per I.
, p. 4533 - 4536 (2006)
Biomimetic oligomers are of large interest both as targets for combinatorial and parallel synthetic efforts and as foldamers. For example, shorter peptoid derivatives of β-peptides, i.e., oligo-N-substituted β-Ala, have been described as potential lead st
Reversal agent and linker variants of reversed chloroquines: Activities against Plasmodium falciparum
Andrews, Simeon,Burgess, Steven J.,Skaalrud, Deborah,Kelly, Jane Xu,Peyton, David H.
supporting information; experimental part, p. 916 - 919 (2010/07/05)
We have shown that "reversed chloroquine molecules" constructed from chloroquine-like and resistance "reversal-agent"-like cores can be powerful drugs against malaria (J. Med. Chem. 2006, 49, 5623-5625). Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental. 2009 American Chemical Society.
AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS
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Page 50, (2010/02/10)
Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is -N- or -CH-; n is from 0 to 3.
