71121-96-5Relevant academic research and scientific papers
Reversal agent and linker variants of reversed chloroquines: Activities against Plasmodium falciparum
Andrews, Simeon,Burgess, Steven J.,Skaalrud, Deborah,Kelly, Jane Xu,Peyton, David H.
supporting information; experimental part, p. 916 - 919 (2010/07/05)
We have shown that "reversed chloroquine molecules" constructed from chloroquine-like and resistance "reversal-agent"-like cores can be powerful drugs against malaria (J. Med. Chem. 2006, 49, 5623-5625). Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental. 2009 American Chemical Society.
Efficient syntheses of oncinotine and neooncinotine
Hou, Duen-Ren,Cheng, Hsiu-Yi,Wang, Eng-Chi
, p. 6094 - 6099 (2007/10/03)
We have synthesized two natural alkaloids, oncinotine (1) and neooncinotine (2), by means of efficient ring-closing metathesis (RCM) reactions. The required dienes for RCM were assembled from three basic components: 2-allylpiperidine (5), 9-decenoic acid (6), and diamines 7. We developed two different methods to achieve the linkage: the Michael addition of acrylamide and two amidations of succinic anhydride. The Grubbs catalyst was used to form the 17- and 18-membered lactams in 50% and 68% yields, respectively.
Ethosuximide assay tracers, immunogens and antibodies
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, (2008/06/13)
The present invention is directed to a fluorescence polarization assay for ethosuximide, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibo
