71138-87-9

Basic information

• Product Name: 3-(2,5-Dimethoxyphenyl)-4-methoxy-3H-isobenzofuran-1-one
• Synonyms: 3-(2,5-Dimethoxyphenyl)-4-methoxy-3H-isobenzofuran-1-one
• CAS NO: 71138-87-9
• Molecular Weight: 300.311
• Mol File: 71138-87-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(2,5-Dimethoxyphenyl)-4-methoxy-3H-isobenzofuran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,5-Dimethoxyphenyl)-4-methoxy-3H-isobenzofuran-1-one(71138-87-9)
• EPA Substance Registry System: 3-(2,5-Dimethoxyphenyl)-4-methoxy-3H-isobenzofuran-1-one(71138-87-9)

Safety Data

• Hazardous Substances Data: 71138-87-9(Hazardous Substances Data)

Upstream product

• 70767-96-3 N-bromo-4-methoxyphthalide 
• 150-78-7 1,4-dimethoxybezene 
• 6833-23-4 3-methoxy-N-phenylbenzamide 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 13161-32-5 4-hydroxy-3H-isobenzofuran-1-one 
• 4792-33-0 4-methoxyphthalide 
• 99-06-9 3-Carboxyphenol 

Downstream Products

• 121364-89-4 2-<2,5-dimethoxybenzyl>-3-methoxybenzoic acid 
• 408356-76-3 4-(2,5-dimethoxy-phenyl)-5-methoxy-isochroman-3-ol 
• 408356-70-7 1-(2,5-dimethoxy-phenyl)-7-methoxy-1,3-dihydro-isobenzofuran 

Relevant articles and documents

Application of organolithium and related reagents in synthesis. Part 25: Novel specific synthesis of the 4-arylisochroman-3-acetic acids via conversion of benzoic acids

The transformation of the benzanilides 1 into 4-arylisochroman-3-acetic acids 8 applying the following sequence of reactions is described. At first, the 3-arylphthalides 3 were obtained via metallation [n-BuLi] of benzanilides 1 and subsequent treatment of the generated bis-lithiated anilides 2 with aromatic aldehydes. Next, the 3-arylphthalides 3 were reduced [LiBH4] to phthalanes 5 and then, via reductive metallation [Li/C10H8] and reaction of the generated bis-lithiated species 6 with dimethylformamide, 3-hydroxy-4-arylisochromans 7 were produced. In the final step the isochromans 7 were treated with 1-methoxy-1-trimethylsilyloxyethene in the presence of titanium tetrachloride and furnished 4-arylisochromans-3-acetic acid methyl esters 8 as trans stereoisomers (Ψ-e/e).

Facile Interconversion of the Isomeric Acid Chlorides Derived from Half Methyl Esters of 3-Methoxyphthalic Acid

The isomeric acid chlorides obtained by treating the half methyl esters of 3-methoxyphthalic acid with thionyl chloride interconvert so readily that it is not practical to isolate one acid chloride free of the other.At equilibrium the main isomer is the a