7115-16-4

Usage

Uses

Used in Pharmaceutical Industry:
1-Chloro-3-methyl-isoquinoline is used as a key intermediate in the synthesis of pharmaceutical compounds, leveraging its chemical structure to create new drugs with potential therapeutic benefits.
Used as an Antimicrobial Agent:
In the field of microbiology, 1-chloro-3-methyl-isoquinoline serves as an antimicrobial agent, utilized for its ability to inhibit the growth of various microorganisms, thereby offering potential applications in treating infections and preserving medical products.
Used in Antitumor Research:
1-Chloro-3-methyl-isoquinoline is used as a subject of antitumor research, where its potential to combat cancer cells is being explored, offering a promising avenue for the development of novel cancer therapies.
Used in Optoelectronic Industry:
In the optoelectronic field, 1-chloro-3-methyl-isoquinoline is used in the development of organic light-emitting diodes (OLEDs) and other optoelectronic applications, capitalizing on its distinctive electronic and photophysical attributes to enhance device performance and efficiency.

InChI:InChI=1/C10H8ClN/c1-7-6-8-4-2-3-5-9(8)10(11)12-7/h2-6H,1H3

Upstream product

• 7114-80-9 3-methylisoquinolin-1-ol 
• 10025-87-3 trichlorophosphate 
• 1125-80-0 3-methylisoquinoline 
• 825-60-5 benzimidic acid ethyl ester 
• 63870-81-5 1-ethoxy-3-methylisoquinoline 
• 29539-21-7 3-methylisocoumarin 
• 14380-86-0 ethyl 2-(1,3-dioxoisoindolin-2-yl)propanoate 
• 5423-95-0 4-hydroxy-3-methyl-2H-isoquinolin-1-one 
• 85-44-9 phthalic anhydride 
• 7114-80-9 3-methylisoquinolone 
• 14548-00-6 3-methylisoquinoline N-oxide 

Downstream Products

• 1125-80-0 3-methylisoquinoline 
• 7114-80-9 3-methylisoquinolin-1-ol 
• 77619-94-4 3-(3-methylisoquinolin-1-yl)isobenzofuran-1(3H)-one 
• 129881-56-7 3-methyl-2-<(3-oxo-1,3-dihydroisobenzofuran-1-yl)carbonyl>isoquinolin-1(2H)-one 
• 27107-35-3 5-Methyl-s-triazolo<3,4-a>isochinolin 
• 1380213-42-2 C₂₃H₂₅N₃O₂ 

Relevant academic research and scientific papers

Synthesis of rhodium(III)-catalyzed isoquinoline derivatives from allyl carbonates and benzimidates with hydrogen evolution

A novel Rh(iii)-catalyzed cascade C-H activation/cyclization approach to access isoquinoline derivatives from benzimidates and available allyl carbonates with the liberation of H2 has been realized. Allyl carbonates were first used as a versati

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

Regioselective Chlorination of Quinoline N-Oxides and Isoquinoline N-Oxides Using PPh3/Cl3CCN

A novel method for the regioselective C2-chlorination of heterocyclic N-oxides has been developed. PPh3/Cl3CCN were used as chlorinating reagents and the desired N-heterocyclic chlorides were obtained smoothly in satisfactory yields. The reactions proceeded in a highly efficient and selective manner across a broad range of substrates demonstrating excellent functional group tolerance. In addition, this chlorination reaction can be used for the modification of N-heterocyclic scaffolds of appealing ligands and pharmaceuticals.

A practical and mild chlorination of fused heterocyclic N-oxides

Fused azine N-oxides were selectively chlorinated at C2 in moderate to excellent yields, employing Vilsmeier reagent as both the activating agent and the nucleophilic chloride source. Remarkable features of the method include simple operation, mild reaction conditions, a wide substrate scope, and the use of only stoichiometric amount of POCl3. The potential extension of this method to a one-pot oxidation/chlorination sequence that obviates the need for isolation of the N-oxide intermediates is also validated.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.

On the Chemistry of Pyrrole Pigments, XCI: Copper Complexes of Pyridinologous Linear Tri- and Tetra-pyrroles as Cyclopropanation Catalysts

In addition to two recently described pyridinologous linear tri- and tetrapyrroles a biisoquinologous system was prepared and its geometrical features derived by means of NMR measurements and force field calculations.The copper complexes of these three ligands were isolated and characterized, and then used as catalysts in the cyclopropanation of styrene.The results were found to be similar to those reported for a variety of catalysts in literature.Thus, it was demonstrated that these systems can be used in principle as catalysts. - Keywords.Pyridinologous linear tri- and tetrapyrroles; Copper chelates; 1H-NMR spectra; Configuration; Conformation; Cyclopropanation catalyst.

Synthesis of some triazolo- and tetrazolo-isoquinolines

The isocoumarins (Ia-c) on treatment with ammonia-ethanol give isoquinolones (IIa-c) which react with POCl3-PCl5 affording 1-chloroisoquinolines (IIIa-c).Further reaction with hydrazine furnishes 1-hydrazinoisoquinolines (