71173-46-1

Basic information

• Product Name: (1E)-1-(3,4-dimethoxyphenyl)ethanone thiosemicarbazone
• Synonyms: 1-(3,4-Dimethoxyphenyl)ethanone thiosemicarbazone
• CAS NO: 71173-46-1
• Molecular Formula: C₁₁H₁₅N₃O₂S
• Molecular Weight: 253.3207
• Mol File: 71173-46-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 389.5°C at 760 mmHg
• Flash Point: 189.4°C
• Density: 1.22g/cm³
• Vapor Pressure: 2.84E-06mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: (1E)-1-(3,4-dimethoxyphenyl)ethanone thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-1-(3,4-dimethoxyphenyl)ethanone thiosemicarbazone(71173-46-1)
• EPA Substance Registry System: (1E)-1-(3,4-dimethoxyphenyl)ethanone thiosemicarbazone(71173-46-1)

Safety Data

• Hazardous Substances Data: 71173-46-1(Hazardous Substances Data)

Usage

General Description

The chemical (1E)-1-(3,4-dimethoxyphenyl)ethanone thiosemicarbazone, also known as DMEPT, is a thiosemicarbazone derivative with potential anti-cancer properties. Thiosemicarbazones have been found to demonstrate anti-tumor activity by inhibiting ribonucleotide reductase, an enzyme that is essential for DNA synthesis and cell proliferation. DMEPT specifically targets cancer cells by inducing DNA damage and apoptosis, leading to the suppression of tumor growth. (1E)-1-(3,4-dimethoxyphenyl)ethanone thiosemicarbazone has shown promise as a potential anti-cancer agent and is the subject of ongoing research for its therapeutic potential in cancer treatment.

Upstream product

• 79-19-6 thiosemicarbazide 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 4346-94-5 thiosemicarbazide hydrochloride 

Downstream Products

• 1389248-78-5 C₁₁H₁₃N₃O₂S₂ 
• 1389248-83-2 C₂₉H₂₈N₃O₂PS 

Relevant articles and documents

Synthesis and Antimicrobial Activity of New Thiazolidine-Based Heterocycles as Rhodanine Analogues

A new series of compounds containing thiazole nucleus as Rhodanine analogues have been synthesized. The new compounds were prepared from the reactions of the thiosemicarbazones (3a,b) with a series of α-halo carbonyl compounds to give the corresponding Rh

Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors

One current approach in the treatment of cancer is the inhibition of cyclin dependent kinase (CDK) enzymes with small molecules. CDK are a class of enzymes, which catalyze the transfer of the terminal phosphate of a molecule of ATP to a protein that acts

Synthesis and evaluation of biological activities of 4-cyclopropyl-5-(2-fluorophenyl) arylhydrazono-2,3-dihydrothiazoles as potent antioxidant agents

A new series of 4-cyclopropyl-5-(2-fluorophenyl)arylhydrazono-2,3-dihydrothiazole derivatives was synthesized via the reaction of prepared thiosemicarbazones with 2-bromo-1-cyclopropyl-2-(2-uorophenyl)ethanone in the presence of Et3 N as a catalyst throug