71173-67-6

Usage

InChI:InChI=1/C12H20OS/c1-10(2)6-5-7-11(3)8-9-14-12(4)13/h6,8H,5,7,9H2,1-4H3/b11-8+

Upstream product

• 141-12-8 neryl acetate 
• 10387-40-3 potassium thioacetate 
• 105-87-3 3,7-dimethyl-2E,6-octadien-1-yl acetate 
• 115-95-7 linalool acetate 
• 106-24-1 Geraniol 
• 507-09-5 tiolacetic acid 

Downstream Products

• 39067-80-6 (E)-3,7-dimethylocta-2,6-dienylmercaptan 

Relevant academic research and scientific papers

Preparation method of thioacetic acid geraniol ester

The invention relates to a preparation method of thioacetic acid geraniol ester. The preparation method comprises the following specific steps: (1) stirring geraniol and thioacetic acid in a dichloromethane solvent to carry out a reaction for 4-10 hours by taking pyridine as a catalyst, and after the reaction is ended, adjusting the pH value of the reaction solution to be neutral to obtain a neutral reaction solution; and (2) extracting the neutral reaction solution obtained in the step (1) by using an organic solvent, drying the obtained organic layer, carrying out filtering, concentrating the filtrate to obtain a crude product, and carrying out column chromatography on the crude product to obtain the thioacetic acid geraniol ester. Compared with the prior art, the preparation method disclosed by the invention is simple in preparation process, convenient in operation and high in yield; purity of the final product thioacetic acid geraniol ester is high; production cost is low; and themethod is suitable for industrial production.

Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites

Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates-Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically evaluated against T. cruzi, the responsible agent of Chagas disease and against Toxoplasma gondii, the etiologic agent of toxoplasmosis and also towards the target enzymes farnesyl pyrophosphate synthase of T. cruzi (TcFPPS) and T gondii (TgFPPS), respectively. The isoprenoid-containing 1,1-bisphosphonates exhibited modest antiparasitic activity, whereas the linear α-fluoro-2-alkyl(amino)ethyl-1,1-bisphosphonates were unexpectedly devoid of antiparasitic activity. In spite of not presenting efficient antiparasitic activity, these data turned out to be very important to establish a structural activity relationship.

Palladium-catalyzed synthesis of allylic thioacetates. A convenient access to allylic thiols

Palladium(0)-catalyzed alkylation of various allylic acetates and carbonates by potassium thioacetate allowed an easy access to allylic thioacetates in rather good yields. The reaction was regioselective with substitution at the less hindered side of the intermediate π-allyl system, and diastereoselective with net retention of configuration.