71183-99-8 Usage
Uses
Used in Pharmaceutical Applications:
24,25-dihydroxyvitamin D2 is utilized as a therapeutic agent for the maintenance of bone health, serving as a preventative measure against conditions such as rickets and osteomalacia. Its role in bone metabolism and calcium regulation makes it a crucial component in the treatment and management of bone-related disorders.
Used in Anti-inflammatory Applications:
Due to its anti-inflammatory properties, 24,25-dihydroxyvitamin D2 is employed as an anti-inflammatory agent, potentially beneficial in the treatment of inflammatory conditions and diseases where inflammation plays a significant role in the pathology.
Used in Immune Function Applications:
24,25-dihydroxyvitamin D2 is used to support immune function, potentially modulating immune responses and contributing to the body's defense mechanisms against infections and other immune challenges.
Used in Cancer Treatment Research:
In the field of oncology, 24,25-dihydroxyvitamin D2 is studied as a potential therapeutic agent for the treatment of various types of cancer. Its role in cell differentiation and proliferation may offer benefits in managing cancer progression and treatment resistance.
Used in Autoimmune Disorder Research:
24,25-dihydroxyvitamin D2 is also being investigated for its potential role in the treatment of autoimmune disorders, where it may help regulate immune responses and reduce the impact of autoimmune attacks on the body's tissues.
Used in Nutritional Supplements:
As a metabolite of vitamin D2, 24,25-dihydroxyvitamin D2 is used in nutritional supplements to support overall health, particularly for individuals who may be at risk of vitamin D deficiency or those with specific health conditions that require additional support in maintaining calcium and phosphorus balance.
Check Digit Verification of cas no
The CAS Registry Mumber 71183-99-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,1,8 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 71183-99:
(7*7)+(6*1)+(5*1)+(4*8)+(3*3)+(2*9)+(1*9)=128
128 % 10 = 8
So 71183-99-8 is a valid CAS Registry Number.
InChI:InChI=1/C28H44O3/c1-19-9-12-23(29)18-22(19)11-10-21-8-7-16-27(5)24(13-14-25(21)27)20(2)15-17-28(6,31)26(3,4)30/h10-11,15,17,20,23-25,29-31H,1,7-9,12-14,16,18H2,2-6H3/b17-15+,21-10+,22-11-/t20-,23-,24-,25+,27-,28-/m1/s1
71183-99-8Relevant academic research and scientific papers
Highly regio- and stereoselective hydroxylation of vitamin D2 by CYP109E1
Putkaradze, Natalia,K?nig, Lisa,Kattner, Lars,Hutter, Michael C.,Bernhardt, Rita
, p. 295 - 300 (2020/01/31)
Vitamin D2 is a form of vitamin D derived from mushrooms and plants which is structurally modified in the body due to the action of several enzymes. The resulting metabolites represent important compounds with potential bioactive properties. However, they are poorly studied and their availability is mostly limited. In order to identify new enzymes capable of producing vitamin D2 metabolites, we investigated a bacterial P450 monooxygenase, CYP109E1, which was previously shown to be a vitamin D3 hydroxylase. It was found that CYP109E1 catalyzes a vitamin D2 two-step hydroxylation at positions C24 and C25 resulting in the generation of 24(R),25-diOH VD2. Interestingly, the enzyme showed high selectivity towards vitamin D2, whereas it showed an unselective product pattern for the structurally similar vitamin D3. Our docking results for vitamin D2 and D3 revealed favorable hydroxylation positions for both substrates and suggested an explanation for the high selectivity of CYP109E1 towards vitamin D2. In addition, we established a whole-cell biocatalyst expressing CYP109E1 in Bacillus megaterium to produce 24(R),25-diOH VD2 and a production yield of 12.3 ± 1.2 mg/L was obtained after 48 h. To the best of our knowledge, this is the first report on the generation of 24(R),25-diOH VD2 by a microbial biocatalyst allowing a low-cost and eco-friendly production of this pharmaceutically interesting and expensive metabolite from the relatively cheap substrate, VD2.
