7120-01-6

Usage

Uses

Used in the Petroleum Industry:
2-(Diaminomethyleneamino)-4-methylthiazole is used as a corrosion inhibitor for its ability to form a protective film on metal surfaces, thereby preventing corrosion.
Used in Pharmaceutical and Agrochemical Synthesis:
2-(Diaminomethyleneamino)-4-methylthiazole is used as a reactant in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new and effective products in these fields.
Used as a Polymerization Catalyst:
2-(Diaminomethyleneamino)-4-methylthiazole is utilized as a polymerization catalyst to facilitate and control the polymerization process, enhancing the production of polymers with desired properties.

Upstream product

• 2114-02-5 amidinothiocarbamide 
• 78-95-5 chloroacetone 
• 598-31-2 1-bromoacetone 
• 67-64-1 acetone 

Downstream Products

• 33633-49-7 4-(4-methoxy-phenyl)-1-(4-methyl-thiazol-2-yl)-1H-imidazol-2-ylamine 
• 33633-50-0 1-(4-methyl-thiazol-2-yl)-4,5-diphenyl-1H-imidazol-2-ylamine 

Relevant academic research and scientific papers

Method for synthesizing 2-guanidinothiazole compound by one-pot process

According to the invention, a substituted methyl ketone compound is innovatively used as a raw material, amidinothiourea is added into an alcohol solvent under the conditions of halogeno salt MX and Oxone, and a one-pot process one-step reaction is carried out to obtain the target 2-guanidinothiazole compound. Common methyl ketone is used for replacing an alpha-halogenated carbonyl compound whichis high in price and toxicity, MX which is low in price and easy to obtain is used as a halogen source, the method is novel, raw materials and reagents are cheap, reaction conditions are mild, and operation is easy and convenient, therefore low-cost, convenient and rapid synthesis of the 2-guanidinothiazole compound is achieved.

Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

Designed from a high throughput screened hit compound, novel 2-amino-1-thiazolyl imidazoles were synthesized and demonstrated cytotoxicity against human cancer cells. 1-(4-Phenylthiazol-2-yl)-4-(thiophen-2-yl)- 1Himidazol- 2-amine (compound 2), a 2-amino-1-thiazolyl imidazole, inhibited tubulin polymerization, interacted with the colchicine-binding sites of tubulins, and caused cell cycle arrest at the G2/M phase in human gastric cancer cells. Disruption of the microtubule structure in cancer cells by compound 2 was also observed. Compound 2 concentration-dependently inhibited the proliferation of cancer cells in histocultured human gastric and colorectal tumors. Given orally, compound 2 prolonged the lifespans of leukemia mice intraperitoneally inoculated with the murine P388 leukemic cells. We report 2-amino-1-thiazolyl imidazoles as a novel class of orally active microtubuledestabilizing anticancer agents. Springer Science+Business Media, LLC 2010.

Imidazolamino compounds

The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.