71200-54-9

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 100-47-0 benzonitrile 
• 140-53-4 p-chlorobenzyl cyanide 
• 455-18-5 4-CF₃C₆H₄CN 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 1166260-69-0 7,10-bis(4-chlorobenzyl)acenaphtho[1,2-d]pyridazine 
• 840-68-6 3-benzyl-5-phenyl-1H-1,2,4-triazole 
• 117594-59-9 7-benzyloxy-3-(4-chlorobenzyl)-6-(4-chlorophenyl)imidazo<1,2-b>-s-tetrazine 
• 117594-58-8 3,7-bis(4-chlorobenzyl)-6-(4-chlorophenyl)imidazo 
• 82481-31-0 3,6-bis(4-chlorobenzyl)-1,4-dihydro-s-tetrazine 
• 82481-37-6 2,5-bis(4-chlorobenzyl)-1,3,4-oxadiazole 
• 82481-36-5 3-(4-chlorobenzyl)-5-(4-chlorophenyl)-1,2,4-triazole 
• 71200-56-1 3-(4-chlorobenzyl)-6-(4-chlorophenyl)-7-methoxyimidazo<1,2-b>-s-tetrazine 
• 82481-36-5 3-(4-chlorobenzyl)-5-(4-chlorophenyl)-1,2,4(4H)-triazole 

Relevant academic research and scientific papers

Synthesis of tetrazines from: Gem -difluoroalkenes under aerobic conditions at room temperature

An efficient and green procedure for the synthesis of tetrazines has been developed based on an old chemistry reported by Carboni in 1958. Both symmetric and asymmetric 3,6-disubstituted 1,2,4,5-tetrazines can be obtained in moderate to high yields from t

Synthesis, structures of some unsymmetrical 3,6-disubstituted-1,2,4,5- tetrazines

(Chemical Equation Presented) A series of new unsymmetrical 3-phenyl-6-benzyl-1,2,4,5-tetrazine derivatives 10a-i were synthesized and characterized by IR, NMR, MS, and element analysis. The structures of 4a, 10c, 10d and 10h were analyzed by X-ray crystallography, which had intermolecular C-H...N, C-H...Cl, C-H...Π and Π...Π H interactions.

Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives

Fourteen compounds of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives were prepared and their structures were confirmed by single-crystal X-ray diffraction and the semi-empirical calculation of PM3 method. This reaction yields the 1,4-dihydro derivatives rather than the 1,2-dihydro derivatives. The central six-membered ring of 1,4-dihydro-1,2,4,5-tetrazine has a chair conformation and therefore is not homoaromatic. Their antitumor activities were evaluated in vitro by SRB method for A-549 and BEL-7402 cells, and MTT method for P-388 and HL-60 cells. The results show that there is one compound which is highly effective against P-388 cells and one compound which is highly effective against HL-60 cells. So it is a kind of compound which possesses potential antitumor activities and is worth to research further.

Synthesis and antitumor activity of s-tetrazine derivatives

Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.