71268-58-1

Upstream product

• 71268-57-0 2,2-dimethyl-6-phenylthiomethylcyclohexanone 
• 1193-47-1 2,2-dimethyl-cyclohexanone 
• 19980-35-9 1-trimethylsilyloxy-2-methyl-1-cyclohexene 
• 71268-56-9 (6,6-Dimethyl-cyclohex-1-enyloxy)-trimethyl-silane 
• 71268-63-8 2-methyl-2-(phenylthiomethyl)-1-cyclohexanone 

Downstream Products

• 54345-56-1 (8,8-dimethyl-4-methylene)-1-oxaspiro<2.5>octane 

Relevant academic research and scientific papers

α-ALKYLATION AND α-ALKYLIDENATION OF CARBONYL COMPOUNDS BY O-SILYLATED ENOLATE PHENYLTHIOALKYLATION

For many reactions next to a carbonyl group, the use of O-silylated enolate chemistry offers improvements in yield and selectivity over the corresponding reactions of Group I metal enolates.In the case of α-alkylation of carbonyl compounds, Lewis acid (TiCl4 or ZnBr2) promoted phenylthioalkylation of O-silylated enolates 3 by α-chlorosulphides 4 (R3=H, Me, Prn, Pri, Bui, and Me3Si), followed by reductive sulphur removal by Raney nickel, 5->6, is found to be a reliable method for this synthetically important C-C bond forming step.An alternative sulphur elimination pathway via the sulphoxide, 5->7, allows the regio- and stereocontrolled α-alkylidenation of carbonyl compounds.The phenylthioalkylation reaction is applicable to ketones, aldehydes, esters, and lactones.

A study of chiral induction in some diene additions catalyzed by chiral alkoxyaluminum dichlorides

A reliable procedure for the preparation of the chiral Lewis acid catalysts, (-)-menthoxy- ((-)-1) and (-)-bornyloxyaluminum dichloride ((-)-2), has been established for the study of diene additions.The geometry of conformationally mobile α,β-unsaturated