71274-57-2

Usage

Uses

Used in Medicinal Chemistry:
2-(phenylsulfonyl)thiazole is used as a building block for the synthesis of new pharmaceutical compounds, leveraging its biological activities and the potential of the phenylsulfonyl group to enhance pharmacological properties.
Used in Drug Discovery Research:
2-(phenylsulfonyl)thiazole is used as a lead compound in drug discovery research, with its antimicrobial, antiviral, and anticancer properties being explored for the development of new therapeutic agents.
Used in Antimicrobial Applications:
2-(phenylsulfonyl)thiazole is used as an antimicrobial agent, targeting various microorganisms due to its inherent biological activity.
Used in Antiviral Applications:
2-(phenylsulfonyl)thiazole is used as an antiviral agent, potentially inhibiting viral replication and spread, based on its demonstrated biological activities.
Used in Anticancer Applications:
2-(phenylsulfonyl)thiazole is used as an anticancer agent, with its potential to interfere with cancer cell growth and proliferation being investigated for the development of novel cancer therapies.

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 139-02-6 sodium phenoxide 
• 873-55-2 sodium benzenesulfonate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 

Relevant academic research and scientific papers

Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y

A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryls following a Homolytic Aromatic Substitution (HAS) pathway. This method has provided a range of α-aminoheteroaryl compounds including a functionalized natural product. The mechanism of this late-stage functionalization of aryls was investigated and suggests the formation of a sulfonyl radical intermediate over a reductive quenching cycle.

Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22-) equivalent. TBSOMS-Na, easily prepared from the commercial reagents Rongalite and TBSCl, serves as a potent nucleophile in S-alkylation and Cu-catalyzed S-arylation reactions with alkyl and aryl electrophiles. The sulfone products thus obtained can undergo the second bond formation at the sulfur center with various electrophiles without a separate unmasking step to afford sulfones and sulfonyl derivatives such as sulfonamides and sulfonyl fluorides.

Nickel-Catalyzed Synthesis of Diaryl Sulfones from Aryl Halides and Sodium Sulfinates

A novel nickel-catalyzed cross-coupling of sulfinic acid salts with aryl halides is described. The reaction provides access to various diaryl sulfones in moderate to excellent yields. A broad range of functional groups and heteroaromatic compounds is tolerated under the reaction conditions.

Sulfonylation of five-membered heterocycles via an SNAr reaction

An efficient, concise, and transition metal-free synthesis of functionalized sulfonylated five-membered heterocyclic compounds via an S NAr reaction has been developed. Using commercially available sodium sulfinates as sulfonylation reagents, various five-membered heterocyclic sulfones were obtained in good yields.

Carbopalladation-sulphonylation of allene: A versatile preparation of 2-vinyl or 2-aryl allyl sulphones

The allene carbopalladation process can be realized with various vinylic or aromatic derivatives, in the presence of sodium benzenesulphinate, and allows the preparation of the entitled sulphones.