71296-95-2

Upstream product

• 95932-17-5 -1 phenyl-5 tetrazole 
• 1145-01-3 3,5-Diphenylpyrazole 
• 98-88-4 benzoyl chloride 
• 94-41-7 benzalacetophenone 
• 25229-59-8 Benzalacetophenon-p-tosylhydrazid 

Downstream Products

• 1145-01-3 3,5-Diphenylpyrazole 
• 1666-86-0 2,4,6-triphenylpyrimidine 

Relevant academic research and scientific papers

Efficient one-pot synthesis of substituted pyrazoles

An efficient, one-pot synthesis of substituted pyrazoles from enones, hydrazides, and halides was developed. In comparison with the classical Knorr pyrazole synthesis, this methodology gave a different type of product (R 3≥R5). A range of substituted pyrazoles were prepared in good to high yields with complete regioselectivity.

Reactivite du nucleophile azoture vis-a-vis de cations heterocycliques aromatiques. VIII. Rearrangement de β-tetrazolo-trans-benzalacetophenones

β-Tetrazolyl-trans-benzalacetophenones (T) isomerize upon heating into the corresponding azido-azomethines (A).These non-isolable products undergo various transformations depending on the reaction conditions.With organic bases such as triphenylphosphine or pyridine, their interception can occur.In aromatic solvents, a rearrangement involving loss of nitrogen leads to five-membered diazoted heterocycles: N-benzoyl imidazoles and pyrazoles, via intermediate diazirines and oxazepines.Protic solvents have been found to facilitate the isomerisation of tetrazoles into azidoazomethines.Solvolysis of the azidooxazine and in some cases of the oxazinium species resulting from the equilibrium and reaction: are then observed.