71308-91-3

Usage

Uses

Used in Organic Synthesis:
2-bromo-5,6,7,8-tetrahydroquinoline is used as a building block in organic synthesis for the creation of various complex organic molecules. Its bromine substituent provides opportunities for further functionalization, making it a versatile component in the synthesis of pharmaceuticals and other organic compounds.
Used in Drug Discovery:
In the pharmaceutical industry, 2-bromo-5,6,7,8-tetrahydroquinoline is used as a starting material for the development of new drugs. Its unique structure and reactivity allow for the design and synthesis of novel drug candidates with potential therapeutic applications.
Used in Medicinal Chemistry:
2-bromo-5,6,7,8-tetrahydroquinoline has potential applications in medicinal chemistry, where it can be used to explore the structure-activity relationships of various biologically active compounds. Its bromine atom can be replaced with other functional groups to investigate the effects on biological activity and selectivity.
Used in Agrochemicals:
In the agrochemical industry, 2-bromo-5,6,7,8-tetrahydroquinoline can be used as a building block for the development of new pesticides or other agrochemicals. Its unique structure and reactivity can contribute to the creation of more effective and environmentally friendly products.
Used in Materials Science:
2-bromo-5,6,7,8-tetrahydroquinoline also has potential applications in materials science, where it can be used to develop new materials with specific properties. Its bromine substituent and tetrahydroquinoline core can be utilized to create materials with unique electronic, optical, or mechanical characteristics.

Upstream product

• 54802-19-6 5,6,7,8-tetrahydro-1H-quinolin-2-one 
• 21172-88-3 2-chloro-5,6,7,8-tetrahydro-quinoline 
• 4594-78-9 cyclohexanone-2-propionitrile 
• 54802-19-6 2-hydroxy-5,6,7,8-tetrahydroquinoline 

Downstream Products

• 1357359-51-3 2-(2-fluorophenyl)-5,6,7,8-tetrahydroquinoline 
• 1357359-55-7 2,6-diisopropyl-N-(2-(5,6,7,8-tetrahydroquinolin-2-yl)phenyl)aniline 
• 1357387-17-7 F₂BC₉H₁₀NC₆H₄NC₆H₃(CH(CH₃)2)2 

Relevant academic research and scientific papers

Pyrazolone-fused pyrimidine compound as well as preparation method and application thereof

The invention discloses a pyrazolone-fused pyrimidine compound as well as a preparation method and application thereof. The invention provides a pyrazolone-fused pyrimidine compound as shown in a formula I which is described in the specification. The pyrazolone-fused pyrimidine compound has better inhibitory activity on WEE1 kinase.

FLUORSCENT DYES WITH LARGE STOKES SHIFTS

Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed. The ligands chelate to a BF2 center to produce the fluorescent dye. The disclosed dyes combine longer Stokes shifts (approximately 100 nm) with increased quantum yields. They are also photostable in aqueous and organic solutions for several hours. These dyes may be used in the labeling of biomolecules for bioimaging and assays. Also disclosed are methods for the synthesis of these dyes.

Heterocyclic compounds as inhibitors of factor VIIa

The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

Synthesis and structure of molecular tweezers containing active site functionality

A series of molecules has been synthesized in which a functional group is buried inside an aromatic binding cleft. These novel compounds, called "molecular tweezers", have a methyl ester (6a, 7-9a, 10a), a carboxylic acid (6b, 9b, 10b, 45), or a nitrile (