71319-21-6

Basic information

• Product Name: (4-methylphenyl)(3-nitrophenyl)methanone
• Synonyms: (3-Nitro-phenyl)-p-tolyl-methanone
• CAS NO: 71319-21-6
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.242
• Mol File: 71319-21-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 407.7°C at 760 mmHg
• Flash Point: 196.5°C
• Density: 1.232g/cm³
• Vapor Pressure: 7.39E-07mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: (4-methylphenyl)(3-nitrophenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methylphenyl)(3-nitrophenyl)methanone(71319-21-6)
• EPA Substance Registry System: (4-methylphenyl)(3-nitrophenyl)methanone(71319-21-6)

Safety Data

• Hazardous Substances Data: 71319-21-6(Hazardous Substances Data)

Usage

General Description

The chemical compound (4-methylphenyl)(3-nitrophenyl)methanone, also known as 3'-nitro-4'-methylbenzophenone, is an organic compound with the molecular formula C14H11NO3. It is a ketone derivative with a nitro group and a methyl group attached to phenyl rings. (4-methylphenyl)(3-nitrophenyl)methanone is commonly used in organic synthesis and is also known for its role as a building block in the production of pharmaceuticals and agrochemicals. It is important to handle this compound with caution, as it may have potential hazards associated with its handling and use in a laboratory or industrial setting.

Upstream product

• 108-88-3 toluene 
• 121-92-6 3-nitrobenzoic acid 
• 29559-27-1 1-methyl-4-(nitromethyl)benzene 
• 585-79-5 m-nitrobromobenzene 
• 106-38-7 para-bromotoluene 
• 34063-52-0 1-Nitro-3-nitromethyl-benzene 
• 645-00-1 m-iodonitrobenzene 
• 5720-05-8 4-methylphenylboronic acid 
• 13939-06-5 molybdenum hexacarbonyl 
• 624-31-7 4-tolyl iodide 
• 13331-27-6 m-nitrobenzene boronic acid 
• 99-94-5 p-Toluic acid 
• 3128-42-5 S-phenyl 4-methylbenzothioate 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 62261-36-3 3-amino-4'-methyl-benzophenone 
• 1353654-34-8 1-(4-(3-nitrobenzoyl)benzoyl)-3-thiosemicarbazide 
• 109044-72-6 diazo-(3-nitro-phenyl)-p-tolyl-methane 
• 58845-17-3 3,3'-diamino-4-methyl-benzophenone 
• 860594-68-9 3'-amino-3-bromo-4-methyl-benzophenone 
• 321879-67-8 4-benzoyl-2-bromotoluene 
• 34564-93-7 1-nitro-3-(1-p-tolylvinyl)benzene 
• 861079-27-8 4-methyl-3,5,3'-trinitro-benzophenone 
• 873388-64-8 4-methyl-3,3'-dinitro-benzophenone 
• 433944-44-6 4-(3-nitrobenzoyl)benzoic acid 
• 861075-01-6 3-bromo-4-methyl-3'-nitro-benzophenone 
• 100867-72-9 4'-methyl-3-nitro-benzophenone-hydrazone 

Relevant articles and documents

Pd-NHC catalysed Carbonylative Suzuki coupling reaction and its application towards the synthesis of biologically active 3-aroylquinolin-4 (1H)-one and acridone scaffolds

We have unfolded a convenient and mild protocol for the synthesis of diaryl ketones via Pd- NHC catalysed carbonylative Suzuki coupling reaction. Notably, this method offers advantages like no use of toxic CO gas, shorter reaction time, high yield, and broad substrate scope. Several sensitive functional groups (like-COMe, -COOMe, -F, -Cl, -Br, -NH2, -CN) are well tolerated in this reaction. In addition, we have also demonstrated a new efficient route for the synthesis of biologically active and pharmaceutically important 2-substituted 3-Aroylquinolin-4(1H)-ones and acridone scaffolds.

Palladium-Catalyzed α-Arylation of Aryl Nitromethanes

Catalytic conditions for the α-arylation of aryl nitromethanes have been discovered using parallel microscale experimentation, despite two prior reports of the lack of reactivity of these aryl nitromethane precursors. The method efficiently provides a variety of substituted, isolable diaryl nitromethanes. In addition, it is possible to sequentially append two different aryl groups to nitromethane. Mild oxidation conditions were identified to afford the corresponding benzophenones via the Nef reaction, and reduction conditions were optimized to afford several diaryl methylamines.

Copper-catalyzed arylation of arylboronic acids with aldehydes

A novel copper-catalyzed arylation of arylboronic acids with aldehydes under oxygen atmosphere was achieved in the presence of Cu(OTf)2 and Xantphos, affording diaryl ketone derivatives in moderate to good yields. The efficiency of this reaction was demonstrated by the compatibility with fluoro, bromo, chloro, nitro, -methylsulfonyl, and trifluoromethyl groups. Georg Thieme Verlag Stuttgart ? New York.