7134-16-9

Upstream product

• 67-56-1 methanol 
• 95-53-4 o-toluidine 
• 618-03-1 3-amino-4-methylbenzenesulfonic acid 
• 97-06-3 4-methyl-3-nitro-benzenesulfonic acid 
• 7134-03-4 3-hydroxy-4-methylbenzenesulfonic acid 
• 77-78-1 dimethyl sulfate 
• 578-58-5 2-methylmethoxybenzene 

Downstream Products

• 89469-32-9 4-Chlorosulphonyl-2-methoxybenzoic acid 
• 72856-73-6 2-methoxy-4-(methylsulfanyl)benzoic acid 

Relevant academic research and scientific papers

Synthesis of 2-Methoxy-4-(methylsulfanyl)benzoic Acid — An Intermediate Product in the Preparation of the Cardiotonic Drugs Sulmazole and Isomazole

Readily available 4-methyl-3-nitrobenzenesulfonic acid and 2-methyl-5-nitrophenol were used to develop two alternative approaches to the synthesis of 2-methoxy-4-(methylsulfanyl)benzoic acid in total yields of 17% and 37%, respectively. The synthesis starting from 2-methyl-5-nitrophenol is more process-oriented and can be used in the resynthesis of Sulmazole and Isomazole.

Sulfonation of 1,2-(methylenedioxy)benzene, 1,2-(ethylenedioxy)benzene, 2-methylanisole, 2,3-dihydrobenzofuran, chromane, benzo-15-crown-5 and dibenzo-30-crown-10 in concentrated sulfuric acid and with sulfur trioxide

The sulfonation of 1,2-(methylenedioxy)benzene (2), 1,2-(ethylenedioxy)benzene (3), benzo-15-crown-5 (4), 2-methylanisole (5), 2,3-dihydrobenzofuran (7), 2,3-dihydrobenzopyran (chromane, 8) and dibenzo-30-crown-10 (9) in concentrated sulfuric acid and wit