7137-77-1

Upstream product

• 23501-97-5 benzoic acid-(4-dimethylamino-benzyl ester) 
• 100-61-8 N-methylaniline 
• 56-23-5 tetrachloromethane 
• 121-69-7 N,N-dimethyl-aniline 
• 13424-22-1 4-(N-methyl-N-phenylamino)-1-butene 
• 3416-49-7 N-butyl-N-methylaniline 
• 613-97-8 N-methyl-N-ethylaniline 
• 128219-88-5 Hexyl-methyl-o-tolyl-amine 
• 128219-89-6 Butyl-(3-chloro-phenyl)-methyl-amine 
• 111-34-2 -butyl vinyl ether 
• 13641-16-2 <(Methylphenylamino)methyl>phenylsulfid 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 50-00-0 formaldehyd 
• 1703-46-4 N,N-dimethyl-4-hydroxymethylaniline 

Downstream Products

• 13557-01-2 (4-N,N-dimethylaminophenyl)methyl phenyl selenide 
• 956-71-8 N,N-dimethyl-4-((phenylthio)methyl)aniline 

Relevant academic research and scientific papers

Direct benzylation of amines with benzylic alcohols catalyzed by palladium/phosphine-borane catalyst system

Direct catalytic benzylation of amines with benzylic alcohols to give benzylamines has been newly developed by using palladium/phosphine-borane catalyst system. In this catalytic reaction, the linking between both phosphine and borane moieties in the ligand is very important. Hydroxy group of benzylic alcohols is activated by Lewis acidic borane to form a benzylpalladium intermediate which is attacked by amines to give benzylamine products.

Aerobic Asymmetric Dehydrogenative Cross-Coupling between Two C sp 3 -H Groups Catalyzed by a Chiral-at-Metal Rhodium Complex

A sustainable C-C bond formation is merged with the catalytic asymmetric generation of one or two stereocenters. The introduced catalytic asymmetric cross-coupling of two Csp3-H groups with molecular oxygen as the oxidant profits from the oxidative robustness of a chiral-at-metal rhodium(III) catalyst and exploits an autoxidation mechanism or visible-light photosensitized oxidation. In the latter case, the catalyst serves a dual function, namely as a chiral Lewis acid for catalyzing enantioselective enolate chemistry and at the same time as a visible-light-driven photoredox catalyst. Green stuff: A sustainable C-C bond formation is merged with the catalytic asymmetric generation of one or two stereocenters by combining asymmetric enolate chemistry with either autoxidation or visible-light photosensitized oxidation. The robustness of a chiral-at-metal rhodium(III) catalyst serves to facilitate the reaction. PMP=para-methoxyphenyl, TFA=trifluoroacetic acid.

Application of lanthanoid catalysts for the synthesis of Michler's hydride

A series of lanthanoid (Ln3+) based Lewis acid catalysts were investigated as alternatives to other metal based catalysts for the formation of Michler's hydride, 4, 4′-methylenebis(N, N-dimethylaniline) (1). The lanthanoid based Lewis acid cata

Photooxidative set initiated N-demethylation of N,N′-dimethylanlines: Mimicking the cytochrome P-450 type oxygenations

Photoinduced single electron transfer initiated selective N-demethylation of N,N′-dialkyl anilines in alkaline methanol is reported.

Iron-catalysed Oxidation of N,N-Dimethylaniline with Molecular Oxygen

N,N-Dimethylaniline is oxidised by molecular oxygen in the presence of a number of iron complexes or salts in acetonitrile to give a mixture of N-methylformanilide and 4,4'-methylenebis(N,N'-dimethylaniline) together with N-methylaniline, the product composition being a marked function of the identity of the iron species employed.

THE INTERVENTION OF OXYGEN IN THE OXIDATION OF N,N-DIMETHYLANILINES WITH FENTON'S REAGENT

N-Dealkylation and nuclear hydroxylation are observed in the treatment of N,N-dimethylanilines with iron(II) and hydrogen peroxide.Oxygen is consumed during the oxidation.Although oxygen activation depends upon pH and concentration of both substrate and hydrogen peroxide, deuterium labelling of substrates and measurements of oxygen consumption provide some information on the mechanism of its activation.