56269-47-7

Upstream product

• 67-56-1 methanol 
• 56288-33-6 4-chloro-N-methyl-N-n-butylaniline 
• 110-68-9 N-n-butyl-N-methylamine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 7332-00-5 n-butylazide 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 74718-98-2 N-butyl-4-methoxy-2-nitroaniline 
• 5350-56-1 4-amino-1-methoxy-3,5-dinitrobenzene 
• 64172-25-4 N-methyl-4-methoxy-2,6-dinitroaniline 
• 64172-26-5 N-Butyl-N-methyl-2,6-dinitro-p-anisidin 
• 64172-27-6 N-Butyl-N-methyl-2-nitro-p-anisidin 
• 366-29-0 N,N,N',N'-tetramethylbenzidine 
• 7137-77-1 N,N-dimethyl-4-{[methyl(phenyl)amino]methyl}aniline 
• 61829-43-4 N-butyl-4-methoxyaniline 

Relevant academic research and scientific papers

Efficient catalytic aryl amination of bromoarenes using 3-iminophosphine palladium(II) chloride

While pursuing the development of new hydroamination catalysts, a 3-iminophosphine palladium(II) chloride complex [(3IP)PdCl2] was synthesized that has subsequently proven to be an effective precatalyst for the aryl amination of bromoarenes. This (3IP)PdCl2 complex has been utilized in the catalytic aryl amination of both bromobenzene and bromopyridine derivatives, specifically yielding excellent activity in coupling reactions involving bromobenzene, 4-bromotoluene, and 2-bromopyridine. Using a standard set of catalytic conditions, many alkyl and aryl amines have been investigated as coupling partners in the aryl amination of bromoarenes. In general, secondary alkyl amines and ortho-substituted anilines proved to be the best substrates for this reaction, commonly giving quantitative conversion to products, while primary amines and other anilines gave only poor to moderate results. Catalytic screening data, product yields, and full characterization of isolated products are included.

Oxidation of Aryldialkylamines with Cerium(IV) Ammonium Nitrate and Thallium(III) Nitrate

Nine alkylmethylanilines were oxidised with cerium(IV)ammonium nitrate and thallium(III) nitrate in acetic acid, acetonitrile, and methanol.Reaction products were those deriving from demethylation, dealkylation, and aromatic nitration at positions ortho and para to the amino-group.The ratio between demethylation and dealkylation and between them and aromatic nitration is discussed in terms of (i) the oxidising power and electrophilicity of the reagent and (ii) the co-ordinative properties of the solvent.