71418-45-6 Usage
Uses
Used in Analytical Chemistry:
QBBR is used as a detection reagent for monitoring protein thiols in cells, allowing researchers to study the distribution and changes in these molecules before and after chemical reduction with disulfides.
Used in Electrophoresis and Cation-Exchange Chromatography:
QBBR is used as a charged bimane derivative for the separation of its conjugates, taking advantage of its positive charge and the differences in membrane permeability and protein accessibility compared to uncharged bimane probes.
Used in Fluorescence Spectroscopy:
QBBR is used as a fluorescent probe in spectroscopic studies, providing valuable information on the interaction of thiols with other molecules due to its fluorescence properties (e x 10-3: 5.0).
Used in Pharmaceutical Research:
QBBR can be employed in the development of drug delivery systems and as a tool for studying protein-protein interactions, given its ability to access sites within proteins and its reactivity with thiols.
Used in Environmental Science:
QBBR can be utilized in the detection and monitoring of thiols in environmental samples, contributing to the understanding of their role in various ecological processes.
Used in Material Science:
QBBR's fluorescence properties can be harnessed in the development of new materials with specific sensing or detection capabilities, particularly in the context of thiol-containing compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 71418-45-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,4,1 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 71418-45:
(7*7)+(6*1)+(5*4)+(4*1)+(3*8)+(2*4)+(1*5)=116
116 % 10 = 6
So 71418-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H19BrN3O2.BrH/c1-8-10(6-14)15-11(7-17(3,4)5)9(2)13(19)16(15)12(8)18;/h6-7H2,1-5H3;1H/q+1;/p-1
71418-45-6Relevant academic research and scientific papers
Bimanes. 6. Reactive halogen derivatives of syn- and anti-1,5-diazabicyclo[3.3.0]octadienediones (9,10-dioxabimanes)
Kosower, Edward M.,Pazhenchevsky, Barak,Dodiuk, Hanna,Kanety, Hannah,Faust, Dov
, p. 1666 - 1673 (2007/10/02)
The preparation of reactive halogen derivatives of syn- and anti-1,5-diazabicyclo[3.3.0]octadienediones (9,10-dioxabimanes) is accomplished through the intermediate monobromo- and dibromobimanes previously described. Mono- and dihydroxy compounds are produced from the bromides by reaction with wet sodium trifluoroacetate in CH3CN and are used to prepare the (a) monochlorides and dichlorides (SOCl2) and (b) the monofluorides and difluorides (Et2NSF3). Monofunctional halides react with nucleophiles (amines, thiols, carboxylates) to yield direct substitution products, with some reduction accompanying the thiol reaction. Difunctional halides react with excess nucleophile to give direct disubstitution products. syn-Dihalides react with difunctional nucleophiles (actual or potential, e.g., RNH2, S2-, (CN)2C2,CH3)B are markedly affected by the nature of X. Most syn-bromobimanes are nonfluorescent and are moderately photosensitive, due to thermally reversible isomerizations and additional irreversible reactions. syra-Chlorobimanes are nonfluorescent to weakly fluorescent. syn-Monofluoro- and difluorobimanes are strongly fluorescent. At 77 K, the halogenated compounds are all phosphorescent to some extent and many of the syn derivatives are strongly fluorescent.
