624736-74-9

Upstream product

• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 623-49-4 ethyl cyanoformate 
• 624736-70-5 (6R)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine 
• 624736-67-0 6-ethoxy-3-(p-methoxyphenyl)-6H-1,2-oxazine 
• 71426-53-4 α-bromo-(p-methoxy)acetophenonoxime 

Downstream Products

• 624736-79-4 (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 624736-80-7 (2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 220585-01-3 ethyl [2S,3R,4S]-2-(4-Methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-pyrrolidine-3-carboxylate 
• 178739-03-2 ethyl (2R,3R,4S)-5-(4-methoxyphenyl)-3-(3,4-(methylenedioxy)phenyl)pyrrolidine-3-carboxylate 

Relevant academic research and scientific papers

Enantioselective synthesis of the pyrrolidine core of endothelin antagonist ABT-627 (Atrasentan) via 1,2-oxazines

Diastereoselective syntheses of the pyrrolidine core 6a of the endothelin antagonist ABT-627 (Atrasentan) either as a racemic mixture or as an enantiopure compound are presented. The crucial steps of these syntheses utilized the highly diastereoselective