71429-16-8Relevant academic research and scientific papers
Quinoline-azetidinone hybrids: Synthesis and in vitro antiproliferation activity against Hep G2 and Hep 3B human cell lines
Alegaon,Parchure,Araujo,Salve,Alagawadi,Jalalpure,Kumbar
, p. 1566 - 1571 (2017)
In search of new heterocyclic anticancer agents, a new quinoline-azetidinone hybrid template have been designed, synthesized and screened for their cytotoxic activity against human cancer cell lines such as Hep G2, and Hep 3B by the MTT assay and results were compared with paclitaxel, 5-fluorouracil and doxorubicin. Interestingly, some of the compounds were found significantly active against both cell lines. The compound 6f (IC50?=?0.04?±?0.01?μM) exhibited potent antiproliferation activity against Hep G2 cell line, and 6j compound (IC50?=?0.66?±?0.01?μM) demonstrated potent antiproliferation activity against Hep 3B cell line and provide to be more potent as cytotoxic agents than standard drugs. Morphological changes suggest the induction of apoptosis and describe the mechanism of action of these hybrid antitumor agents.
Synthesis and evaluation of anti-Tuberculosis and anti-cancer activities of hydrazones and N-Acylhydrazones by using sonochemistry, a new general procedure
Da Silveira Pinto, Ligia S.,De Souza, Marcus V. N.,Kaiser, Carlos R.
, p. 678 - 685 (2017/07/15)
Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-Acylhydrazones in drug discovery, in this work we report a new general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus assisted by ultrasound and their respective anti-Tuberculosis and anti-cancer activities. Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against cancer and TB, respectively. Conclusion: Unfortunately all new hydrazones and N-Acylhydrazones evaluated displayed no activity anti cancer and TB.
Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives
Candea, Andre L.P.,Ferreira, Marcelle de L.,Pais, Karla C.,Cardoso, Laura N.de F.,Kaiser, Carlos R.,Henriques, Maria das Gracas M.de O.,Lourenco, Maria C.S.,Bezerra, Flavio A.F.M.,de Souza, Marcus V.N.
scheme or table, p. 6272 - 6274 (2010/06/20)
A series of twenty-one 7-chloro-4-quinolinylhydrazones (3a-u) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 3f, 3i and 3o were non-cytotoxic and exhibited a
