71432-30-9Relevant academic research and scientific papers
Synthesis and spectroscopic analysis of substituted 2-aminothiazolines
Ferreira, Renan B.,Tormena, Claudio F.,Almeida, Wanda P.
, p. 186 - 190 (2013/05/22)
2-Aminothiazolines can exist in two tautomeric species, amino and imino forms, which can theoretically exist as two stereoisomers. Several methods and techniques have been used to evaluate tautomeric process, but in this case 15N NMR spectrosco
Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines
Hirashima, Akinori,Yoshii, Yutaka,Eto, Morifusa
, p. 1062 - 1065 (2007/10/02)
2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid-catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2-thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)-2-thiazolines were obtained by alkylating 2-mercaptothiazoline.Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords; the effect of introducing substituents at the phenyl of the SBAT compounds on octopaminergic agonist activity was not significant. 2--2-thiazolines and 2-(alkylthio)-2-thiazolines were not significant octopaminergic agonists.Washing removed nearly all of the activity of one of the SBAT compounds, suggesting that the SBAT compounds bound reversibly to the octopaminergic receptor.
Synthesis of new 'benzyl'-thiourea derivatives and their cyclic analogues with diuretic and saluretic activity
Reiter,Toldy,Schafer,et al.
, p. 41 - 53 (2007/10/02)
A series of new 'benzyl'-thiourea derivatives 2 and their cyclic analogues 3 were synthesized and tested for diuretic activity. The structure-activity relationships - being also computed - are discussed. Some selected compounds were studied in detail for
