19975-56-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(METHYLTHIO)-2-THIAZOLINE is used as a pharmaceutical intermediate for the synthesis of novel triand tetracyclic hetero systems. Its unique chemical structure allows it to react with heteroaromatic 2-aminoesters, leading to the formation of complex and potentially bioactive molecules.
Additionally, 2-(METHYLTHIO)-2-THIAZOLINE is used in the preparation of 2-(2-chlorobenzylamino)-2-thiazoline, which is another important intermediate in the development of pharmaceutical compounds. The versatility of 2-(METHYLTHIO)-2-THIAZOLINE in forming various heterocycles makes it a valuable asset in the design and synthesis of new drugs with potential therapeutic applications.

InChI:InChI=1/C4H7NS2/c1-6-4-5-2-3-7-4/h2-3H2,1H3

Upstream product

• 134469-06-0 thiazolidine-2-thione 
• 74-88-4 methyl iodide 
• 96-53-7 2-mercaptothiazoline 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 67-56-1 methanol 
• 35317-02-3 2-phenethylsulfanyl-4,5-dihydro-thiazole 
• 56158-48-6 (2-hydroxy-ethyl)-dithiocarbamic acid methyl ester 
• 23546-72-7 (2-chloro-ethyl)-thiocarbonochloridimidic acid methyl ester 

Downstream Products

• 81440-91-7 2-<<<5-(1,1-dimethylethyl)-2-hydroxy-3-iodophenyl>methyl>amino>-4,5-dihydrothiazole 
• 71432-30-9 N-(1-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine 
• 72239-34-0 (2-chloro-benzyl)-(4,5-dihydro-thiazol-2-yl)-amine 
• 63012-75-9 2,3-dihydro-5H-thiazolo[2,3-b]pteridin-5-one 
• 1779-81-3 2-imino-2,3,4,5-tetrahydrothiazole 
• 161715-27-1 1-(1,3-thiazolin-2-yl-)azetidin-3-ol 

Relevant academic research and scientific papers

A convenient synthesis of new annelated pyrimidines and their biological importance

Several bicyclic/tricyclic-fused pyrimidines were synthesized from the reactions of amino esters and bifunctional nucleophiles such as 2-methylthio-thiazoline and 2-methylthio-imidazoline. The synthesized compounds were tested for their in vitro antimicrobial activities that revealed mild to moderate growth inhibitory potentials.

N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (I), or a salt thereof wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ανβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

Method for synthetizing Tebipenem intermediate

The invention discloses a method for synthetizing a Tebipenem intermediate, and belongs to the field of chemical pharmacy. 2- methylthio-4, 5- thiazoline is synthetized by using ethanolamine as a raw material, a disulfide bond and a C-N coupling and breaking disulfide bond are formed through addition, cyclization, open loop and hydrolysis by using allyl amine as a raw material, and finally the Tebipenem intermediate namely 1- ( 4,5- thiazoline -2- base) azetidine -3- mercaptide hydrochloride is synthetized. The method disclosed by the invention is simple and easy to operate, high in yield, low in pollution and suitable for industrial production.

S-methylation of N-containing heterocyclic thiols with conjugated acids of methoxy groups

2-Mercaptopyridine-3-carboxylic acid reacts with methanol under acidic conditions to afford the corresponding S-methylated methyl ester, methyl 2-methylthiopyridine-2-carboxylate. Such S-methylation occurred for various N-containing heterocyclic thiols wi

4,5-Dihydrothiazoline - A new protecting and activating group for generation of α-aminocarbanions of secondary amines

4,5-Dihydrothiazoline has been successfully used as a protecting and activating group for synthesis of various 1-substituted 1,2,3,4- tetrahydroisoquinolines via a lithiation-electrophillic substitution reaction sequence. Copyright Taylor & Francis Group, LLC.

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.

Formation and Rearrangement of Cyclic Semi-aminals with α-Mercapto Groups

Reaction of thioacetic acid, thiobenzoic acid as well as 2-aminothiophenol with racemic cyclic semi-aminal 3 takes a diastereoselective course to racemic 4a, b, c.The ambident thiazolidine-2-thione reacts analogously, however by attack of nitrogen yielding 4d.The possibilities for rearrangement of adducts 4 are discussed and the structure of the rearranged products is examinated by x-ray analysis of 9c as well as by 13C NMR spectroscopy.The course of the diastereoselective rearrangement to the racemic mixture (α/β) of 2-azaspirononenes 9a-d is discussed by aid of the results.