19975-56-5

Basic information

• Product Name: 2-(METHYLTHIO)-2-THIAZOLINE
• Synonyms: 2-(Methylsulfanyl)-4,5-dihydro-1,3-thiazole;2-(Methylthio)thiazoline;2-Thiazoline, 2-(methylthio)-;2-(METHYLMERCAPTO)-2-THIAZOLINE;2-(METHYLTHIO)-2-THIAZOLINE;4,5-dihydro-2-(methylthio)thiazole;2-(METHYLTHIO)-2-THIAZOLINE 99+%;2-(Methylthio)-4,5-dihydro-1,3-thiazole
• CAS NO: 19975-56-5
• Molecular Formula: C₄H₇NS₂
• Molecular Weight: 133.24
• EINECS: 243-447-9
• Product Categories: chemical additive;pharmaceutical intermediate;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Thiazolines/Thiazolidines
• Mol File: 19975-56-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 216-217 °C(lit.)
• Flash Point: 208 °F
• Appearance: /
• Density: 1.226 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.205mmHg at 25°C
• Refractive Index: n20/D 1.592(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.74±0.10(Predicted)
• BRN: 106353
• CAS DataBase Reference: 2-(METHYLTHIO)-2-THIAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLTHIO)-2-THIAZOLINE(19975-56-5)
• EPA Substance Registry System: 2-(METHYLTHIO)-2-THIAZOLINE(19975-56-5)

Safety Data

• Safety Statements: 23-24/25
• RIDADR: UN 3334
• WGK Germany: 3
• F: 8-9-13
• Hazardous Substances Data: 19975-56-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 19975-56-5 differently. You can refer to the following data:
1. thiazolidin e thione pharmaceutical intermediate
2. 2-(Methylthio)-2-thiazoline has been used in the preparation of:novel tri- and tetracyclic hetero systems, via reaction with heteroaromatic 2-aminoesters2-(2-chlorobenzylamino)-2-thiazoline

InChI:InChI=1/C4H7NS2/c1-6-4-5-2-3-7-4/h2-3H2,1H3

Upstream product

• 35317-02-3 2-phenethylsulfanyl-4,5-dihydro-thiazole 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 96-53-7 2-mercaptothiazoline 
• 134469-06-0 thiazolidine-2-thione 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 56158-48-6 (2-hydroxy-ethyl)-dithiocarbamic acid methyl ester 
• 23546-72-7 (2-chloro-ethyl)-thiocarbonochloridimidic acid methyl ester 

Downstream Products

• 1779-81-3 2-imino-2,3,4,5-tetrahydrothiazole 
• 65686-74-0 α-trifluoromethyl 2-benzylamino thiazoline 
• 737822-89-8 N-(4-{(E)-2-[4-(4,5-dihydro-1,3-thiazol-2-ylamino)phenyl]ethenyl}-1,3-thiazol-2-yl)acetamide 
• 737824-82-7 N-{4-[2-(4-(4,5-dihydro-1,3-thiazol-2-ylamino)phenyl)ethyl]-5-[4-(methylsulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide 
• 183365-33-5 N-(4-(2-(4-(4,5-dihydro-1,3-thiazol-2-ylamino)phenyl)ethyl)-1,3-thiazol-2-yl)acetamide 
• 161715-27-1 1-(1,3-thiazolin-2-yl-)azetidin-3-ol 
• 99840-84-3 2-(4-Methoxybenzylamino)-2-thiazoline 

Relevant articles and documents

A convenient synthesis of new annelated pyrimidines and their biological importance

Several bicyclic/tricyclic-fused pyrimidines were synthesized from the reactions of amino esters and bifunctional nucleophiles such as 2-methylthio-thiazoline and 2-methylthio-imidazoline. The synthesized compounds were tested for their in vitro antimicrobial activities that revealed mild to moderate growth inhibitory potentials.

Method for synthetizing Tebipenem intermediate

The invention discloses a method for synthetizing a Tebipenem intermediate, and belongs to the field of chemical pharmacy. 2- methylthio-4, 5- thiazoline is synthetized by using ethanolamine as a raw material, a disulfide bond and a C-N coupling and breaking disulfide bond are formed through addition, cyclization, open loop and hydrolysis by using allyl amine as a raw material, and finally the Tebipenem intermediate namely 1- ( 4,5- thiazoline -2- base) azetidine -3- mercaptide hydrochloride is synthetized. The method disclosed by the invention is simple and easy to operate, high in yield, low in pollution and suitable for industrial production.

4,5-Dihydrothiazoline - A new protecting and activating group for generation of α-aminocarbanions of secondary amines

4,5-Dihydrothiazoline has been successfully used as a protecting and activating group for synthesis of various 1-substituted 1,2,3,4- tetrahydroisoquinolines via a lithiation-electrophillic substitution reaction sequence. Copyright Taylor & Francis Group, LLC.