71444-75-2

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 82635-61-8 9-hydroxy-5,11-dioxo-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine 
• 774-48-1 (diethoxymethyl)benzene 
• 18944-39-3 ethyl 1-(3-benzyloxy-4-methyl-2-nitrobenzoyl)-L-prolinate 
• 78205-49-9 9-benzyloxy-8-methyl-5,11-dioxo-2,3,4,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine 
• 33305-75-8 L-proline ethyl ester monohydrochloride 
• 7536-35-8 2-nitro-3-benzyloxy-4-methylbenzoyl chloride 

Downstream Products

• 71444-85-4 9,11-dihydroxy-8-methyl-5-oxo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine 
• 92210-82-7 C₂₀H₂₀N₂O₃ 

Relevant academic research and scientific papers

LIMITATIONS AND FACTORS AFFECTING THE LACTAM REDUCTION APPROACH TO THE SYNTHESIS OF ANTHRAMYCIN ANALOGS

The limitations and factors affecting the hydride reduction of pyrrolobenzodiazepine-5,10-diones to anthramycin-type analogs have been explored.

Studies on Anticancer Agents: Synthesis of Some Anthramycin Analogs and Actinocinyl Diamides

9,11-Dihydroxy-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolobenzodiazepine (11) and actinocinyldipyrrolidines (4 and 5) have been synthesized starting from 3-benzyloxy-4-methyl-2-nitrobenzamides (2 and 3).Catalytic hydrogenation of 2 and 3 followed by oxidative dimerisation affords actinocinyldipyrrolidines ( 4 and 5).Ethyl 1-(3-benzyloxy-4-methyl-2-nitrobenzoyl)-L-prolinate (2) on reduction, followed by acid-catalysed cyclisation, hydrogenolysis, protection of the o-aminophenol functionality by preparing benzylidien derivative, NaBH4 reduction and deblocking gives required pyrrolobenzodiazepine (11).

Pyrrolo benzodiazepine compounds

Novel perhydro-1H-pyrrolo[2,1-C][1,4]benzodiazepin-5-one compounds having antitumor activity, perhydro-1H-pyrrolo[2,1-C][1,4]-benzodiazepin-5,11-dione compounds which are synthetic intermediate of the former, and processes for producing these compounds.