33305-75-8

Basic information

• Product Name: H-PRO-OET HCL
• Synonyms: L-PROLINE ETHYL ESTER HYDROCHLORIDE;H-PRO-OET HCL;ethyl L-prolinate hydrochloride;Pro-OEt HCl;(S)-Proline ethyl ester hydrochloride;(S)-Ethyl pyrrolidine-2-carboxylate hydrochloride;(S)-Pyrrolidine-2-carboxylic acid ethyl ester hydrochloride;Proline ethyl ester hydrochloride
• CAS NO: 33305-75-8
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.64
• EINECS: 251-449-6
• Mol File: 33305-75-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 191.3°Cat760mmHg
• Flash Point: 69.5°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.519mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: H-PRO-OET HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-PRO-OET HCL(33305-75-8)
• EPA Substance Registry System: H-PRO-OET HCL(33305-75-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 33305-75-8(Hazardous Substances Data)

Usage

General Description

H-PRO-OET HCL, also known as Proline ethyl ester hydrochloride, is a chemical compound often used in the field of biochemistry. Proline is an amino acid, vital to protein structure, and its ethyl ester hydrochloride variant is primarily used in peptide synthesis applications. The structure of this compound gives it the ability to form specific types of peptide bonds. Its hydrochloride salt form enhances its stability and makes it more manageable to use in different experimental conditions. Due to these properties, H-PRO-OET HCL is a critical material in biochemistry and pharmaceutical research.

InChI:InChI=1/C7H13NO2.ClH/c1-2-10-7(9)6-4-3-5-8-6;/h6,8H,2-5H2,1H3;1H/t6-;/m0./s1

Upstream product

• 64-17-5 ethanol 
• 147-85-3 L-proline 
• 72-19-5 L-threonine 
• 135097-23-3 (2S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 

Downstream Products

• 18944-39-3 ethyl 1-(3-benzyloxy-4-methyl-2-nitrobenzoyl)-L-prolinate 
• 89311-11-5 N-benzoyl S-proline ethyl ester 
• 23037-82-3 ethyl ester of N-acetyl-L-proline 
• 23037-82-3 (S)-ethyl 1-acetylpyrrolidine-2-carboxylate 
• 97409-49-9 ethyl (S)-N-benzoylformylprolinate 
• 216671-81-7 1-Benzoylaminocarbothioyl-pyrrolidine-2-carboxylic acid ethyl ester 
• 185757-21-5 N-carbobenzoxy-γ-aminobutyrylproline ethyl ester 
• 68-95-1 (S)-acetylproline 
• 131476-72-7 N-stearoyl-L-Ser-L-Pro-OEt 
• 89311-29-5 8a(S)-6,7,8,8a-tetrahydro-4-methylpyrrolo<1,2-d><1,2,4>triazin-1(2H)-one 
• 89311-30-8 8a(S)-6,7,8,8a-tetrahydro-4-phenylpyrrolo<1,2-d><1,2,4>triazin-1(2H)-one 
• 89311-23-9 (S)-ethyl 1-(phenylcarbonothioyl)pyrrolidine-2-carboxylate 
• 1621435-13-9 tert-butyl 2-(((2S, 3R)-1, 3-bis (benzyloxy)-1-oxobutan-2-yl) carbamoyl)-2-(hydroxymethyl) pyrrolidine-1-carboxylate 
• 1621435-28-6 tert-butyl 2-((2S, 3R)-1, 3-bis (benzyloxy)-1-oxobutan-2-yl)-1-oxo-2, 5-diazaspiro [3.4] octane-5-carboxylate 

Relevant articles and documents

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A (1 R, 3 S) -3 - amino-cyclopentanol hydrochloride preparation method (by machine translation)

The invention discloses a (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride of the preparation method, the method using chiral carboxylic acid with hydroxylamine to form the amide as chiral source, in copper catalyzed oxidation in the reaction system to rapidly obtain a chiral Diels - alder reaction product, after passes through the reduction reaction and alkaline deprotection reaction, and acidified after reaction to obtain the target product. Chiral inducing reagent chiral carboxylic acid by simple acidification, extraction processing can be reclaimed and reused. This kind of (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride preparation method has high operation safety and high selectivity, raw materials are easy, and the cost is low, the reaction time is short and simple process flow and the like. (by machine translation)

The reactions of α-amino acids and α-amino acid esters with high valent transition metal halides: synthesis of coordination complexes, activation processes and stabilization of α-ammonium acylchloride cations

Titanium tetrachloride smoothly reacted with a selection of α-amino acids (aaH) in CH2Cl2 affording yellow to orange solid coordination compounds, 1a-d, in 70-78% yields. The salts [NHEt3][TiCl4(aa)], 2a-b, were obtained from TiCl4/aaH/NEt3 (aa = l-phenylalanine, N,N-dimethylphenylalanine), in 60-65% yields. The complex , 3, was isolated from the reaction of l-proline with NbCl5/NHiPr2, performed in CH2Cl2 at room temperature. The X-ray structure of 3 features a bridging (E)-1,2-bis(3,4-dihydro-2H-pyrrol-5-yl)ethene-1,2-diolate ligand, resulting from the unprecedented C-C coupling between two proline units. Unusually stable α-ammonium acyl chlorides were prepared by the reactions of PCl5/MCln (MCln = NbCl5, WCl6) with l-proline, N,N-dimethylphenylalanine, sarcosine and l-methionine. MX5 (M = Nb, Ta; X = F, Cl) reacted with l-leucine methylester and l-proline ethylester to give ionic coordination compounds, [MX4L2][MX6] (M = Nb, L = Me2CHCH2CH(NH2)CO2Me, X = F, 9; Cl, 11a; M = Nb, X = Cl, , 11c; Ta, 11d), in moderate to good yields. [NbCl5(Me2CHCH2CHNH3CO2Me)][NbCl6], 12, was isolated as a co-product of the reaction of NbCl5 with l-leucine isopropylester, and crystallographically characterized. The reaction of NbCl5 with l-serine isopropylester afforded NbCl3(OCH2CHNHCO2iPr), 13, in 66% yield. The activation of the ester O-R bond was observed in the reactions of l-leucine methyl ester with NbF5 and l-proline ethyl ester with MBr5 (M = Nb, Ta), these reactions proceeding with the release of EtF and EtBr, respectively. All the metal products were characterized by analytical and spectroscopic methods, while DFT calculations were carried out in order to provide insight into the structural and mechanistic aspects.