71447-81-9 Usage
Description
Z-ABU-OSU is a novel crosslinker that contains an N-hydroxysuccinimide (NHS) ester and an amino reactive isocyanate group. It is a versatile and useful reagent for coupling amine-containing molecules and proteins through the formation of stable amide bonds. The NHS ester group allows for specific labeling of primary amines in proteins and peptides, making it an effective tool for protein-protein and protein-ligand conjugation in biochemical and biophysical studies. Z-ABU-OSU is water soluble and stable in aqueous solutions, making it suitable for various research applications.
Uses
Used in Biochemical and Biophysical Studies:
Z-ABU-OSU is used as a crosslinking reagent for protein-protein and protein-ligand conjugation. Its NHS ester group allows for specific labeling of primary amines in proteins and peptides, enabling the study of protein interactions and the development of novel bioconjugates.
Used in Drug Delivery Systems:
Z-ABU-OSU can be used as a crosslinking agent in the development of drug delivery systems. Its ability to form stable amide bonds between amine-containing molecules and proteins can be utilized to create targeted drug delivery systems, improving the specificity and efficacy of therapeutic agents.
Used in Research and Development:
Z-ABU-OSU is used as a versatile reagent in various research applications, including the development of new bioconjugates, the study of protein interactions, and the development of novel drug delivery systems. Its water solubility and stability in aqueous solutions make it a valuable tool for researchers working in diverse fields.
Check Digit Verification of cas no
The CAS Registry Mumber 71447-81-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,4,4 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71447-81:
(7*7)+(6*1)+(5*4)+(4*4)+(3*7)+(2*8)+(1*1)=129
129 % 10 = 9
So 71447-81-9 is a valid CAS Registry Number.
71447-81-9Relevant articles and documents
Structure-Activity Study of 5-Substituted 1-Carbobenzoxy-2-iminohydantoins as Potential Anticonvulsant Agents
Sun, Zhong-Yue,Kwon, Chul-Hoon,Wurpel, John N. D.
, p. 2841 - 2845 (2007/10/02)
On the basis of our previous findings, a series of 5-substituted 2-iminohydantoins has been synthesized and tested for anticonvulsant activity to better understand the SAR of 2-iminohydantoins.Among the compounds tested, (S)-(+)-1-carbobenzoxy-2-iminohydantoin analogs with ethyl (6)-, n-propyl (7a)-, isopropyl (8)-, allyl (9)-, and sec-butyl (11)-substituted groups at the C5 of the iminohydanotin ring provided the best activities against the MES test with ED50 values in the range of 52-74 mg/kg.All of the above compounds except 8 also showed activity against the scMET test with ED50 values in the range of 141-223 mg/kg.All significantly active compounds (1, 6, 7a, 8, 9, and 11) possesed aliphatic hydrocarbon side chains of two- to three-carbon lengths at the C5 position.All of the compounds with no or minimal activity had either shorter or longer side chains.The compounds substituted at the C5 position by aryl groups, arylalkyl groups, or alkyl and arylalkyl groups containing heteroatoms also showed no activity against the MES and scMET tests.The results suggested that the C5 side chain with the correct stereochemistry in 2-iminohydantoins provides optimal anticonvulsant activity when the side chains are aliphatic hydrocarbons with a lenght, ignoring branchingg, of two to three carbons.
