71450-13-0Relevant academic research and scientific papers
Removal of some commonly used protecting groups in peptide syntheses by catalytic transfer hydrogenation with formic acid and 10% palladium on carbon
Gowda, D. Channe
, p. 1064 - 1067 (2007/10/03)
It is shown that HCOOH, a good solvent for most peptides, can be conveniently used as a hydrogen donor for catalytic transfer hydrogenation with less expensive 10% Pd on C when compared to palladium black. The protecting groups that are being successively removed include the Nα-benzyloxycarbonyl, Nε-2-chlorobenzyloxycarbonyl, C-terminal benzyl ester, O-benzyl ether of O-benzyltyrosine, serine or threonine, nitro of nitroarginine and Nim-benzyloxymethyl of histidine.
Catalytic Transfer Hydrogenation in Pepetide Synthesis: Synthesis of 5- and 5-enkephalins
Sivanandaiah, K. M.,Gurusiddappa, S.
, p. 857 - 859 (2007/10/02)
The simplicity in the removal of N-protecting groups like benzyloxycarbonyl employed in peptide synthesis by catalytic transfer hydrogenation at room temperature using formic acid in presence of palladium black has been demonstrated by the synthesis of the opioid pentapeptides 5- and 5-enkephalins.
