71455-62-4Relevant articles and documents
Acylhydrocarbylaminoalkanoic acids, compositions and uses
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, (2008/06/13)
Compounds of the formula STR1 wherein R is (a) optionally-substituted and optionally-hydrogenated biphenylyl, (b) optionally-substituted and optionally-hydrogenated bicyclic aryl having from 8 to 12 ring carbon atoms or (c) a radical of the formula STR2 R1 is aliphatic hydrocarbyl, alicyclic hydrocarbyl or optionally-substituted phenyl; R2 is --H or lower aliphatic hydrocarbyl; R3 is --H, lower alkyl, cycloalkyl, optionally-substituted phenyl or, with R4, alkylene; R4 is lower alkyl, cycloalkyl, optionally-substituted phenyl, optionally-(nuclearly)-substituted phenalkyl or, with R3, alkylene; or R2,R3 and R4, together with the carbon to which each is bound, are adamantyl; and n is 3, 4 or 5; and salts thereof with a base are pharmacologically active. Esters thereof are valuable intermediates for the preparation of the pharmacologically-active compounds. Physiologically-acceptable embodiments are administered, e.g., in the form of an appropriate pharmaceutical composition to warm-blooded animals for protection against and treatment for stomach, intestine, pancreas, bile and liver disorders. Syntheses of pharmacologically-active components, transforming toxic embodiments to physiologically-acceptable principles, compounding such principles into pharmaceutical compositions and using such principles for preventing and treating the noted disorders are discussed.
