71472-57-6

Usage

Uses

Used in Pharmaceutical Industry:
6-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE is used as a chemical intermediate for the synthesis of various drugs and medications. Its unique structure and properties make it a valuable component in the development of new pharmaceutical compounds.
Used in Research and Development:
6-METHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE is also used in research and development for the exploration of new chemical compounds and their potential applications. Its versatility and stability contribute to its utility in scientific investigations and the advancement of chemical knowledge.

Upstream product

• 857070-70-3 2-(4-methyl-2-nitro-phenoxy)-ethanol 
• 1247390-41-5 2-(4-methyl-2-nitrophenoxy)acetonitrile 
• 156564-82-8 2-(2-amino-4-methyl-phenoxy)-ethanol 
• 431994-40-0 (4-methyl-2-nitro-phenoxy)-acetic acid ethyl ester 
• 119-33-5 4-methyl-2-nitrophenol 
• 39522-26-4 6-methyl-4H-benzo[1,4]oxazin-3-one 
• 106-93-4 ethylene dibromide 
• 95-84-1 3-amino-4-hydroxytoluene 

Downstream Products

• 915160-98-4 (6-methyl-2,3-dihydro-benzo[1,4]oxazin-4-yl)-acetic acid benzyl ester 

Relevant academic research and scientific papers

METHODS FOR PREPARING COMPOUNDS

A method is provided for preparing a compound d having the formula: Formula (I). The method comprises carrying out the following reaction: Formula (i), (ii), (d) where: step (i) is carried out in the presence of a metal catalyst and a hydrogen source; and

METHODS FOR PREPARING COMPOUNDS

A method is provided for preparing a compound d having the formula (D) The method comprises carrying out the following reaction (c) → (d), where the reaction is carried out at a temperature of at least 100 °C and in the presence of a metal catalyst.

METHODS FOR PREPARING INTERMEDIATES

A method is provided for preparing an intermediate d having the formula: (I). The method comprising carrying out the following one-pot reaction: (II) wherein step (i) is carried out in the presence of a solvent and step (ii) is carried out in the presence

METHODS FOR PREPARING BENZOXAZINES

A method is provided for preparing a compound ?. The method comprises carrying out the following reaction: (i), (ii), (iii) where: PG represents a protecting group, LG represents a leaving group, and L and L' are independently selected from OH and leaving

Design, synthesis, and bioevaluation of substituted phenyl isoxazole analogues as herbicide safeners

Herbicide safeners enhance herbicide detoxification in crops without affecting target weed sensitivity. To enhance crop tolerance to the toxicity-related stress caused by the herbicide acetochlor (ACT), a new class of substituted phenyl isoxazole derivatives was designed by an intermediate derivatization method as herbicide safeners. Microwave-assisted synthesis was used to prepare the phenyl isoxazole analogues, and all of the structures were confirmed via IR, 1H NMR, 13C NMR, and HRMS. Compound I-1 was further characterized by X-ray diffraction analysis. Bioassay results showed that most of the obtained compounds provided varying degrees of safening against ACT-induced injury by increasing the corn growth recovery, glutathione content, and glutathione S-transferase activity. In particular, compound I-20 showed excellent safener activity against ACT toxicity, comparable to that of the commercial safener benoxacor. Gaussian calculations have been performed and the results indicated that the nucleophilic ability of compound I-20 is higher than that of benoxacor, thus the activity is higher than that of benoxacor. These findings demonstrate that phenyl isoxazole derivatives possess great potential for protective management in cornfields.

METHODS FOR PREPARING FUEL ADDITIVES

A method is provided for preparing a fuel additive having the formula: ( l ) The method comprises carrying out the following reactions: (i) addition of an alkylating agent b to starting material a: (a) to form an intermediate c; and (ii) ring closing intermediate c to form fuel additive e.

METHODS FOR PREPARING FUEL ADDITIVES

A method for preparing a substituted fuel additive d is provided. The method comprises carrying out the following reaction: (a) (b) (d), The fuel additive d may be used as an octane-boosting additive in a fuel for a spark- ignition internal combustion eng

METHODS FOR PREPARING FUEL ADDITIVES

A method for preparing a fuel additive d is provided. The method comprises carrying out the following reaction: (l) The fuel additive d may be used as an octane-boosting additive in a fuel for a spark, ignition internal combustion engine.

Design, synthesis and evaluation of novel trichloromethyl dichlorophenyl triazole derivatives as potential safener

The dominance of safener can unite with herbicides acquiring the efficient protection of crop and qualifying control of weeds in agricultural fields. In order to solve the crop toxicity problem and exploit the novel potential safener for fenoxaprop-P-ethyl herbicide, a series of trichloromethyl dichlorobenzene triazole derivatives were designed and synthesized by the principle of active subunit combination. A total of 21 novel substituted trichloromethyl dichlorobenzene triazole compounds were synthesized by substituted aminophenol and amino alcohol derivatives as the starting materials, using cyclization and acylation. All the compounds were unambiguously characterized by IR,1H-NMR,13C-NMR, and HRMS. A greenhouse bioassay indicated that most of the title compounds could protect wheat from injury caused by fenoxaprop-P-ethyl at varying degrees, in which compound 5o exhibited excellent safener activity at a concentration of 10 μmol/L and was superior to the commercialized compound fenchlorazole. A structure–activity relationship for the novel compounds was determined, which demonstrated that those compounds containing benzoxazine groups showed better activity than that of oxazole-substituted compounds. Introducing a benzoxazine fragment and electron-donating group to specific positions could improve or maintain the safener activity for wheat against attack by the herbicide fenoxaprop-P-ethyl. A molecular docking model suggested that a potential mechanism between 5o and fenoxaprop-P-ethyl is associated with the detoxication of the herbicide. Results from the present work revealed that compound 5o exhibited good crop safener activities toward wheat and could be a promising candidate structure for further research on wheat protection.

SUBSTITUTED BENZOXAZINE AND RELATED COMPOUNDS

The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.