7149-80-6

Basic information

• Product Name: 5-CHLORO-4-METHYL-2-NITROANILINE
• Synonyms: TIMTEC-BB SBB003703;5-CHLORO-2-NITRO-P-TOLUIDINE;5-CHLORO-4-METHYL-2-NITROANILINE;5-Chloro-4-methyl-2-nitroaniline, 95+%;5-Chloro-4-methyl-2-nitroaniline,96%;4-Amino-2-chloro-5-nitrotoluene;5-Chloro-4-methyl-1-amino-2-nitrobenzene;NSC 72334
• CAS NO: 7149-80-6
• Molecular Formula: C₇H₇ClN₂O₂
• Molecular Weight: 186.6
• Product Categories: Amines and Anilines;NULL
• Mol File: 7149-80-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 159-163 °C
• Boiling Point: 339.3 °C at 760 mmHg
• Flash Point: 159 °C
• Appearance: Orange-brown/Crystalline Powder
• Density: 1.415 g/cm³
• Vapor Pressure: 9.3E-05mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.79±0.25(Predicted)
• CAS DataBase Reference: 5-CHLORO-4-METHYL-2-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-4-METHYL-2-NITROANILINE(7149-80-6)
• EPA Substance Registry System: 5-CHLORO-4-METHYL-2-NITROANILINE(7149-80-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 7149-80-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7ClN2O2/c1-4-2-7(10(11)12)6(9)3-5(4)8/h2-3H,9H2,1H3

Upstream product

• 7149-78-2 5-chloro-4-methyl-2-nitroacetanilide 
• 95-74-9 3-chloro-p-toluidine 
• 95-49-8 2-methylchlorobenzene 
• 121-86-8 2-chloro-4-nitrotoluene 
• 6973-13-3 2-nitro-4-methyl-5-chlorobenzenesulfonic acid 
• 7664-41-7 ammonia 
• 7149-79-3 N-(3-chloro-4-methylphenyl)acetamide 
• 7697-37-2 nitric acid 
• 7149-77-1 1,5-dichloro-2-methyl-4-nitrobenzene 
• 56136-79-9 2-chloro-4,5-dinitro-toluene 

Downstream Products

• 81449-96-9 5-chloro-N,4-dimethyl-2-nitroaniline 
• 473547-12-5 (5-chloro-4-methyl-2-nitro-phenyl)-carbamic acid tert-butyl ester 
• 1207983-79-6 ethyl 7-(2-amino-5-chloro-4-methylphenylamino)heptanoate 
• 1207983-93-4 tert-butyl 7-[(2-amino-5-chloro-4-methylphenyl)amino]heptanoate 
• 1207984-53-9 ethyl 7-[(2-amino-5-cyclopropyl-4-methylphenyl)amino]heptanoate 
• 1207984-52-8 ethyl 7-[(5-cyclopropyl-4-methyl-2-nitrophenyl)amino]heptanoate 
• 1207985-38-3 tert-butyl 7-[(2-amino-5-cyclopropyl-4-methylphenyl)amino]heptanoate 
• 1207985-37-2 tert-butyl 7-[(5-cyclopropyl-4-methyl-2-nitrophenyl)amino]heptanoate 
• 23617-77-8 4-methyl-5-(4-methylpiperazin-1-yl)-2-nitroaniline 
• 1351585-61-9 4-methyl-2-nitro-5-(2-(pyridin-4-yl)-1H-benzo[d]imidazol-5-yl)aniline 
• 1338684-89-1 4-methyl-N-(3-phenylpropyl)-5-propylbenzene-1,2-diamine 
• 1338684-88-0 4-methyl-2-nitro-N-(3-phenylpropyl)-5-propylaniline 
• 1338684-87-9 7-methyl-10-(3-phenylpropyl)-8-propylbenzo[g]pteridine-2,4(3H,10H)-dione 

Relevant articles and documents

MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS

A compound of formula (I): as well as pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compound. The compound is useful for the treatment of disorder selected from inflammatory diseases, nociceptive pain, auto-imm

Cardiotonic Agents. Synthesis and Cardiovascular Properties of Novel 2-Arylbenzimidazoles and Azabenzimidazoles

Novel 2-arylbenzimidazoles and azabenzimidazoles were synthesized, and their inotropic action was evaluated.Changes in left ventricular pressure, dP/dt max, were measured as an index of cardiac contractility.The structural features that impart optimal inotropic activity are presented.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers.To investigate the mechanism of action, the most potent compounds were tested for their calcium-sensitizing properties and their potential for the inhibition of phosphodiesterase.Two compounds, 1 and 41, showed interesting in vitro and oral activity without side effects.They have a more potent calcium-sensitizing effect than MCI-154 and are under further investigation.

Synthesis of 6-Chloro-1,5-dimethylbenzimidazole

The title compound 6-chloro-1,5-dimethylbenzimidazole (VI) has been synthesized from 5-chloro-4,N-dimethyl-2-nitroaniline (X) which was prepared by two independent methods.