7149-80-6

Usage

InChI:InChI=1/C7H7ClN2O2/c1-4-2-7(10(11)12)6(9)3-5(4)8/h2-3H,9H2,1H3

Upstream product

• 95-74-9 3-chloro-p-toluidine 
• 95-49-8 2-methylchlorobenzene 
• 121-86-8 2-chloro-4-nitrotoluene 
• 6973-13-3 2-nitro-4-methyl-5-chlorobenzenesulfonic acid 
• 7664-41-7 ammonia 
• 7149-79-3 N-(3-chloro-4-methylphenyl)acetamide 
• 7697-37-2 nitric acid 
• 7149-77-1 1,5-dichloro-2-methyl-4-nitrobenzene 
• 7149-78-2 5-chloro-4-methyl-2-nitroacetanilide 
• 56136-79-9 2-chloro-4,5-dinitro-toluene 

Downstream Products

• 63155-04-4 4-chloro-5-methylbenzene-1,2-diamine 
• 7149-77-1 1,5-dichloro-2-methyl-4-nitrobenzene 
• 859794-01-7 2-chloro-4-iodo-5-nitro-toluene 
• 34633-67-5 5-chloro-4-methyl-2-nitro-benzoic acid 
• 131885-58-0 4-Methyl-5-(2-methyl-imidazol-1-yl)-2-nitro-phenylamine 
• 131885-57-9 4-Methyl-5-(4-methyl-imidazol-1-yl)-2-nitro-phenylamine 
• 131885-59-1 5-(2,4-Dimethyl-imidazol-1-yl)-4-methyl-2-nitro-phenylamine 
• 81449-96-9 5-chloro-N,4-dimethyl-2-nitroaniline 
• 89640-05-1 3-chloro-4-methyl-2,6-dinitro-aniline 
• 131885-80-8 4-Imidazol-1-yl-5-methyl-benzene-1,2-diamine 
• 131886-04-9 4-Methyl-5-(4-methyl-imidazol-1-yl)-benzene-1,2-diamine 
• 131885-81-9 4-Methyl-5-(2-methyl-imidazol-1-yl)-benzene-1,2-diamine 
• 131886-05-0 4-(2,4-Dimethyl-imidazol-1-yl)-5-methyl-benzene-1,2-diamine 
• 99923-15-6 2-amino-4-methyl-5-chloro-N-methylaminobenzene 

Relevant academic research and scientific papers

MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS

A compound of formula (I): as well as pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compound. The compound is useful for the treatment of disorder selected from inflammatory diseases, nociceptive pain, auto-imm

FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.

Cardiotonic Agents. Synthesis and Cardiovascular Properties of Novel 2-Arylbenzimidazoles and Azabenzimidazoles

Novel 2-arylbenzimidazoles and azabenzimidazoles were synthesized, and their inotropic action was evaluated.Changes in left ventricular pressure, dP/dt max, were measured as an index of cardiac contractility.The structural features that impart optimal inotropic activity are presented.The most potent compounds were evaluated orally in conscious dogs with implanted Konigsberg pressure transducers.To investigate the mechanism of action, the most potent compounds were tested for their calcium-sensitizing properties and their potential for the inhibition of phosphodiesterase.Two compounds, 1 and 41, showed interesting in vitro and oral activity without side effects.They have a more potent calcium-sensitizing effect than MCI-154 and are under further investigation.

2-(Guanidino)-anilides and related compounds. Synthesis and anthelmintic activity. 3rd Communication: Anthelmintics

Anilides bearing a guanidino, thioallophanato, isothioallophanato or amidino group in the ortho position were synthesized for investigations of their anthelmintic effects, and tested against sheep trichostrongylides. The most active anilides are those containing a 5-alkylthio, 5-alkylsulphinyl (alkyl = C3H7, C4H9), 5-phenylthio, 5-phenylsulphinyl or 4-phenylsulphonyloxy group, and a guanidino group substituted at both nitrogen atoms by a methoxycarbonyl group. The most active anthelmintic anilides are the form-, propion-, butyr- and methoxy-acetanilides. Of the guanidines unsubstituted at N' and N'', the 2-guanidino-5-phenylthio-2-methoxyacetanilide and the 2-guanidino-5-phenylsulphinyl-2-methoxyacetanilide were more active than parbendazole. From the class of bismethoxycarbonylguanidines, which are also the most interesting products in terms of stability, febantel (Rintal) has been introduced into veterinary practice for the treatment of nematode infections in horses, cattle, sheep and swine.

Synthesis of 6-Chloro-1,5-dimethylbenzimidazole

The title compound 6-chloro-1,5-dimethylbenzimidazole (VI) has been synthesized from 5-chloro-4,N-dimethyl-2-nitroaniline (X) which was prepared by two independent methods.