71491-88-8Relevant articles and documents
Metal-Free Hydrosilylation of Ketenes with Silicon Electrophiles: Access to Fully Substituted Aldehyde-Derived Silyl Enol Ethers
Roy, Avijit,Oestreich, Martin
, p. 8273 - 8276 (2021/05/11)
Little-explored hydrosilylation of ketenes promoted by main-group catalysts is reported. The boron Lewis acid tris(pentafluorophenyl)borane accelerates the slow uncatalyzed reaction of ketenes and hydrosilanes, thereby providing a convenient access to the new class of β,β-di- and β-monoaryl-substituted aldehyde-derived silyl enol ethers. Yields are moderate to high, and Z configuration is preferred. The corresponding silyl bis-enol ethers are also available when using dihydrosilanes. The related trityl-cation-initiated hydrosilylation involving self-regeneration of silylium ions is far less effective.
Affinity and selectivity at M2 and M3 muscarinic receptor subtypes of cyclic and open oxygenated analogues of 4-DAMP
Tumiatti,Recanatini,Minarini,Melchiorre,Chiarini,Budriesi,Bolognesi
, p. 1133 - 1147 (2007/10/02)
Two series of cyclic (13-24) and open (25-33) phenyl substituted analogues of 1,1-dimethyl-4-diphenylacetyloxy-piperidinium iodide (4-DAMP, 1) have been synthesized and tested to evaluate their affinity and selectivity for M2 and M3
