714975-83-4

Basic information

• Product Name: (S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-{2-[(4R,6R)-4-methoxycarbonylmethyl-3-(4-methylcarbamoyl-benzyl)-2-oxo-[1,3]oxazinan-6-yl]-ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester
• CAS NO: 714975-83-4
• Molecular Weight: 608.775
• Mol File: 714975-83-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-{2-[(4R,6R)-4-methoxycarbonylmethyl-3-(4-methylcarbamoyl-benzyl)-2-oxo-[1,3]oxazinan-6-yl]-ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-{2-[(4R,6R)-4-methoxycarbonylmethyl-3-(4-methylcarbamoyl-benzyl)-2-oxo-[1,3]oxazinan-6-yl]-ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(714975-83-4)
• EPA Substance Registry System: (S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-{2-[(4R,6R)-4-methoxycarbonylmethyl-3-(4-methylcarbamoyl-benzyl)-2-oxo-[1,3]oxazinan-6-yl]-ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(714975-83-4)

Safety Data

• Hazardous Substances Data: 714975-83-4(Hazardous Substances Data)

Upstream product

• 75330-75-5 lovastatin 
• 67-56-1 methanol 
• 109273-98-5 α,β-dehydrolovastatin 
• 530-62-1 1,1'-carbonyldiimidazole 
• 164648-64-0 4-(aminomethyl)-N-methylbenzamide 

Relevant articles and documents

Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: Stabilization of the metabolically labile vanillyl side chain

Modification of the vanillyl substituent on a potent, semisynthetic lymphocyte function-associated antigen (LFA)-1/intercellular adhesion molecule (ICAM)-1 binding inhibitor of the statin family resulted in metabolically more stable analogues that displayed submicromolar inhibitory activity in vitro and considerable anti-inflammatory activity in vivo. The benzodioxole derivative 2b emerged with the best overall profile.