714978-30-0Relevant articles and documents
A bivalent ligand (KMN-21) antagonist for μ/κ heterodimeric opioid receptors
Zhang, Shijun,Yekkirala, Ajay,Tang, Ye,Portoghese, Philip S.
, p. 6978 - 6980 (2009)
In an effort to develop antagonists for κ-μ opioid receptor heterodimers, a series of bivalent ligands 3-6 containing κ- and μ-antagonist pharmacophores were designed and synthesized. Evaluation of the series in HEK-293 cells revealed 4 (KMN-21) to select