714978-26-4Relevant articles and documents
Discovery of N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1)
Lunk, Ina,Litty, Felix-Alexander,Hennig, Sven,Vetter, Ingrid R.,Kotthaus, Jürke,Altmann, Karin S.,Ott, Gudrun,Havemeyer, Antje,Garciá, Carmen Carrillo,Clement, Bernd,Schade, Dennis
supporting information, p. 425 - 432 (2020/02/04)
N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine (8a) is a potent inhibitor targeting the hDDAH-1 active site (Ki = 18 μM) and derived from a series of guanidine- A nd amidine-based inhibitors. Its nonamino acid nature leads to high selectivities