71504-03-5

Usage

Uses

Used in Organic Synthesis:
1-(3-BROMO-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE is used as a building block in the organic synthesis industry for the production of various chemicals. Its unique structure allows it to serve as a key intermediate in the synthesis of a range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(3-BROMO-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE is utilized as a building block for the development of new pharmaceuticals. Its structural properties make it a valuable component in the creation of novel drug candidates with potential therapeutic applications.

InChI:InChI=1/C11H11BrOS2/c1-14-11(15-2)7-10(13)8-4-3-5-9(12)6-8/h3-7H,1-2H3

Upstream product

• 75-15-0 carbon disulfide 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 74-88-4 methyl iodide 

Downstream Products

• 81874-66-0 (E)-1,5-Bis-(3-bromo-phenyl)-3-methylsulfanyl-pent-2-ene-1,5-dione 
• 1610889-08-1 1-(3-bromophenyl)-3,3-bis(methylthio)-2-(trifluoromethyl)prop-2-en-1-one 
• 1610889-29-6 3-(3-bromophenyl)-5-(methylthio)-4-(trifluoromethyl)-1H-pyrazole 

Relevant academic research and scientific papers

Transition metal free synthesis of multifunctional thiomethylated-benzenes from aryl/heteroaryl/cyclopropyl methyl ketones

A base-promoted strategic synthesis of various functionalized thiomethylated-benzenes has been established from aryl/heteroaryl/cyclopropyl methyl ketone. We can directly access the thiomethylated-benzene nucleus embedded with diverse functional group by

Synthesis of Partially Reduced Imidazo[1,2- a ]pyridines through an Unprecedented Base-Mediated (4+2) Cyclization

A water-mediated regioselective synthesis of 6,7-diaryl-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-a]pyridine-6-carbonitriles was performed by the reaction of 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile with 1-aryl-2-(imidazolidin-2-ylidene)ethanones un

Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold

Hepatitis C Virus exhibits high genetic diversity. The current treatment for genotype-1 with ～80% sustained virologic responses is a combination of pegylated interferon, ribavirin and boceprevir/telaprevir/simeprevir which is associated with several side

Bronsted acid catalyzed PhSe transfer versus radical aryl transfer: Linear codimerization of styrenes and internal olefins

Bronsted acid p-TsOH·H2O-catalyzed hydrovinylation of styrenes with internal olefins α-oxo ketene dithioacetals was efficiently achieved in the presence of N-phenylselenophthalimide (N-PSP), regioselectively affording Markovnikov phenylselenati

Copper-catalyzed trifluoromethylation of internal olefinic C-H bonds: Efficient routes to trifluoromethylated tetrasubstituted olefins and N-heterocycles

The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF 3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.

Base mediated synthesis of α-aminated aroyl/acetylnaphthalenes through [4+2] annulations

We have developed a base promoted simple, efficient and alternative approach for the synthesis of 4-amino-3-aroyl//heteroaroyl/acetyl-2-methylsulfanyl-naphthalene-1-carbonitriles by reaction of easily accessible 3,3-bis(methylthio)-1-aryl/heteroaryl/acety

Infrared Spectra and Theoretical Study of the Conformations of Substituted Benzoylketene-S,S-acetals

The C=O stretching frequencies of substituted benzoylketene-S,S-dimethylacetals (1a-1o) and benzoylketene-S,S-ethyleneacetals (2a-2m) were measured in CHCl3 and CCl4 and correlated with the Hammett substituent constants.The correlations were split into tw