71526-54-0Relevant academic research and scientific papers
An efficient green multi-component reaction strategy for the synthesis of highly functionalised pyridines and evaluation of their antibacterial activities
Reddy, Lakkireddy Srinivasula,Reddy, Tirumalareddy Ram,Mohan, Reddy Bodireddy,Mahesh, Avula,Lingappa, Yeramanchi,Reddy, Nallagondu Chinna Gangi
, p. 1114 - 1120 (2014/01/06)
An efficient green multi-component reaction (MCR) method has been developed for the synthesis of 2-amino-4-aryl/heteroaryl-6-(pyridin-2-ylthio)pyridine-3, 5-dicarbonitrile(s) via a 3-component reaction of aryl aldehyde(s), malononitrile and 2-mercaptopyridine in the presence of K2CO 3 under solvent free reaction conditions (SFRC) using grinding technique at room temperature in a single step. The advantages of the present protocol is operationally simple, environmentally benign, solvent-free reaction conditions (SFRC), simple work up, excellent isolated yields of desired products and viable method for large scale applications in pharmaceutical industry. Interestingly, the synthesized compounds showed moderate to excellent antibacterial activities against Gram-positive and Gram-negative bacterial strains.
The synthesis of some derivatives based on the 4-Benzyl-1H-Pyrazole-3,5- Diamine core
Jedinak, Lukas,Krystof, Vladimir,Cankara, Petr
experimental part, p. 371 - 383 (2011/04/15)
The three-step synthesis of 4-benzyl-1H-pyrazole-3,5-diamines 2 from commercially available aldehydes 3 is given. The Knoevenagel condensation was utilized to assemble the initial carbon framework, resulting in the benzylidenemalononitriles 4 which were d
Monosubstituted malononitriles: Efficient one-pot reductive alkylations of malononitrile with aromatic aldehydes
Tayyari, Fariba,Wood, Dwight E.,Fanwick, Phillip E.,Sammelson, Robert E.
, p. 279 - 285 (2008/12/22)
A powerful new one-pot method has been developed for the reductive alkylation of malononitrile with aromatic aldehydes. This new procedure has vastly improved the yield and efficiency of the process, and increased the scope of the aromatic aldehydes. Inco
