7153-55-1Relevant academic research and scientific papers
Enantioselective Organocatalyzed Michael Additions of Nitroalkanes to 4-Arylidenedihydrofuran-2,3-diones and 4-Arylidenepyrrolidine-2,3-diones
Fofana, Mouhamadou,Dudognon, Yohan,Bertrand, Laura,Constantieux, Thierry,Rodriguez, Jean,Ndiaye, Ibrahima,Bonne, Damien,Bugaut, Xavier
supporting information, p. 3486 - 3490 (2020/05/18)
Tremendous efforts have been devoted to the development of organocatalytic enantioselective Michael additions of nitroalkanes to α,β-unsaturated carbonyl compounds. However, using highly substituted electrophiles remain challenging, since the additional substituents decrease the electrophilicity. β-Arylidene-α-ketolactones and α-ketolactams are used as highly electrophilic Michael acceptors that afford the corresponding products in moderate to good yields, with high enantioselectivities. This success relies on their rigid structure that prevents deconjugation and the efficient recognition of the α-dicarbonyl motif by the hydrogen-bond donor catalyst.
Substituted γ-Lactones. 35 . Reduction of 4-Aroyl-3-hydroxy-2(5H)-furanones
Zimmer, Hans,Manning, M. J.,Ventura, M.,Amer, Adel,Massry, Abdel Monem El
, p. 199 - 202 (2007/10/02)
The reduction of 4-aroyl-3-hydroxy-2(5H)-furanons 1a-c was investigated using different reducing agents.Sodium borohydride reacts with type 1 compounds by loss of water to yield 4-(arylmethylene)-2,3(4H,5H)-furandiones 2a-c.Platinum or charcoal supported
